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aneuploidy |
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aneuploidy [′a·nyü‚plȯid·ē] (genetics) Deviation from a normal haploid, diploid, or polyploid chromosome complement by the presence in excess of, or in defect of, one or more individual chromosomes. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Chromosome 21 disomy in the spermatozoa of fathers of children with trisomy 21 in a population with a high prevalence of Down syndrome: increased incidence in cases of paternal origin. In a smaller number of cases, the syndrome is the result of uniparental disomy in which the maternal contribution to chromosome 15q is replicated, replacing the paternal contribution (Knoll, Nicholls, Magenis, & Graham, 1989). Because uniparental disomy is rare, Malcolm says, these parents can be assured that the syndromes "would be unlikely to recur. |
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