distal convoluted tubule

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distal convoluted tubule

[′dist·əl ‚kän·və′lüd·əd ′tü·byül]
(anatomy)
The portion of the nephron in the vertebrate kidney lying between the loop of Henle and the collecting tubules.
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Pathophysiology of drug-induced nephropathy Level of the nephron Action Drugs Preglomerular Afferent arteriolar Cyclosporine (afferent arteriole) constriction Glomerulus Decreased GFR NSAIDs (prostaglandins) Gold, NSAIDs Glomerulonephritis Penicillamine, cisplatin Proximal tubules Acute tubular necrosis Aminoglycosides, radiocontrast dyes Distal tubules Renal tubular ACE inhibitors, acidosis type 4 cyclosporine Tubules and ducts Crystalluria Acyclovir, sulphonamide Interstitium Interstitial nephritis Penicillin, allopurinol Renal papilla Papillary necrosis NSAIDs, analgesics Table 2.
The distal tubules contain distinctive, atypical casts that typically appear hypereosinophilic, pale with periodic acid-Schiff stain, and polychromatic (mixed red and blue) and lamellated with Masson trichrome stain.
Renin release is stimulated by hypovolaemia, hypotension or decreased sodium in the filtrate passing through the distal tubules.
As mentioned previously, LLC-PK1 cells are considered to be of proximal tubular origin where as MDCK cells are related to the distal tubules and collecting ducts (Gstraunthaler et al.
THIAZIDE DIURETICS Top choice for patients with reasonable renal function, Subclass works on kidneys' distal tubules.