Disulfide Bonds


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Disulfide Bonds

 

(—S—S— bonds), bonds that are formed by the union of sulfur atoms of two mercapto groups. Crosslinking of polypeptide chains containing residues of the amino acid cysteine takes place with the formation of disulfide bonds.

References in periodicals archive ?
5%) is a first-in-class new chemical entity that targets a biochemical cause of presbyopia, believed to be associated with an increase in the formation of disulfide bonds between the crystalline proteins within lens fiber cells.
We aim to detect motion within the receptor on the angstrom scale by trapping conformational states during activation with artificial metal ion binding sites and disulfide bonds.
The tertiary structure of a protein is the three-dimensional structure and is stabilized by the series of hydrophobic amino acid residues and by disulfide bonds formed among two cysteine amino acid.
PolyTherics has developed ThioBridge(TM) for site-specific conjugation of cytotoxic payloads to disulfide bonds in proteins and antibodies to provide more stable and less heterogeneous drug conjugates.
They are based on alkaline reducing agents that swell the hair and break the disulfide bonds.
Because plants are able to produce recombinant proteins the same way mammalian cell cultures do, including post-translational modifications like disulfide bonds among others.
NAC will break disulfide bonds, creating two sulfhydryl molecules.
Sulfur is important for supporting disulfide bonds between collagen fibrils helping to preserve the pliancy of our skin," said Rodney Benjamin, technical director for Bergstrom Nutrition.
Bacteria often do not form the correct disulfide bonds in recombinantly expressed proteins.
Six cysteine residues in defensin were arranged in such a way that three disulfide bonds could be established.
Approximately 30% of the total homocysteine is in the free form, with the rest bound through disulfide bonds to cysteine residues in proteins, mainly albumin (4).
Six cysteines in each EGF repeat form three disulfide bonds (gold).