disulfide bond

(redirected from Disulfide bridges)
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disulfide bond

[dī¦səl‚fīd ′bänd]
(organic chemistry)
References in periodicals archive ?
She said, 'It helps in stiffening of outer dense fibers by formation of disulfide bridges or strong bonding protein molecules during sperm maturation, which is an essential step for generation of sperm motility, especially progressive motility as shown in the study.
For example, the formation of disulfide bridges within the peptide will create 'protein folding' containing the carbon-14 label.
2015) Extracellular disulfide bridges stabilize TRPC5 dimerization, trafficking, and activity.
The mutagenesis data allowed for concluding that the presence of disulfide bridges is not required for folding of the Na,K-ATPase [alpha]-subunit and its subsequent activity [24].
The first class contains 60-70 amino acids cross linked by four disulfide bridges (Gordon et al.
Structure of papain composed of a single polypeptide chain having 3 disulfide bridges and papain enzymatic activity can be determined through sulfhydryl group.
The mannoproteins of yeast can form disulfide bridges with sulfur compounds and lessen their aromatic impact.
The hepatic peptide hormone hepcidin is a highly conserved molecule of only 25 amino acids with 4 disulfide bridges that plays a central role in body iron metabolism (2).
Nonetheless, Fab antibody fragments are much more difficult to produce than other therapeutic proteins, as they are composed of two different protein subunits and contain several disulfide bridges.
Substitution of cysteine by arginine damages the disulfide bridges which influence the secondary structure of the enzyme.
This method may not be applicable for recombinant SK purification from other bacterial sources, as they may secret proteins lacking disulfide bridges.
Disulfide bridges play a major role in stabilization, the folding process and so, existence of cysteine residues and disulfide bonding pattern were determined using DISULFIND server (9).