disulfide bond

(redirected from Disulphide bond)
Also found in: Medical.

disulfide bond

[dī¦səl‚fīd ′bänd]
(organic chemistry)
References in periodicals archive ?
Secretion of recombinant soluble Thy-1 was achieved by stabilizing the terminal Cys 111 residue which takes part in intramolecular disulphide bond formation, by the addition of the tripeptide GGS at the C-terminus (32).
The present discovery was published in a paper titled "Ero-1L alpha plays a key role in a HIF-1-mediated pathway to improve disulphide bond formation and VEGF secretion under hypoxia: implication for cancer" in Oncogene 2005 Feb 3; 24(6): 1011-20.
By supporting intact protein analysis, peptide mapping, N- and C-terminal analysis, glycopeptides and released glycans, and prediction of disulphide bonds, Genedata Expressionist for MS helps users with the analysis of the following MS-based applications:
Although largely resistant, disulphide bonds are broken in alkaline environments (pH 10-14); this explains why afro-textured hair is 'relaxed' permanently using sodium hydroxide or guanidine hydroxide (so-called lye and no-lye relaxers respectively).
The normal kind of bonds - disulphide bonds - can be broken by changes in heat and acidity, causing proteins to lose their 3D structure.