helicase

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helicase

[′hel·ə‚kās]
(biochemistry)
An enzyme that is capable of unwinding the deoxyribonucleic acid double helix at a replication fork.
References in periodicals archive ?
Instead, in vivo DNA replication methods for most organisms rely on a class of enzymes known as DNA helicases, which act to locally unwind dsDNA to create small ssDNA regions suitable for polymerase activity.
Other topics include mediation and modulation of membrane-cytoskeleton interactions, metal binding affinity and selectivity in metalloproteins, translocation and unwinding mechanisms of RNA and DNA helicases, and the structure of eukaryotic RNA polymerases.
For seven years (1994-2001), AGENE conducted research aimed at clarifying the mechanism of human aging and extensively studied several genetic disorders that are caused by the mutation of DNA helicases and show premature aging phenotypes, including Werner syndrome.
Interactions between DNA helicases and frozen topoisomerase IV-quinolone-DNA ternary complexes.