CMX001 is a broad-spectrum antiviral agent with demonstrated activity against multiple double-stranded DNA viruses
, initially being developed by Chimerix for the treatment of viral infections in immunocompromised transplant patients.
Evolutionary genomics of nucleo-cytoplasmic large DNA viruses
CMX001 has demonstrated broad-spectrum activity in preclinical tests against double-stranded DNA viruses
- including CMV - and has been well-tolerated to date among volunteers and patients.
, including herpesviruses and adenoviruses (AdVs), have also been detected in bats, although with less clear implications regarding the role of bats as sources of infection for other mammals (5-8).
The two lead molecules, IQP-0568 and IQP-0589 have also been shown to be active non-nucleoside inhibitors of HIV replication, but inactive against a panel of other RNA and DNA viruses
, suggesting specificity for antiviral activity against viruses that encode a reverse transcriptase.
Hypotheses such as possible arthropod-borne or parasite-associated transmission require careful evaluation, bearing in mind that parvoviruses, in common with other DNA viruses
, are highly host species specific, and no other instances of vector-borne transmission in this virus family have been recorded.
Estimated sales of antivirals to combat both DNA viruses
, including poxviruses, herpesviruses and adenoviruses, as well as RNA viruses such as rubella virus and orthomyxoviruses, rose by nearly 20% from 2004 to 2006, with report findings showing a continuing growth trend resulting in a more than 9% cumulative annual growth rate from 2004 to 2011.
Polyomaviruses are small nonenveloped DNA viruses
, with a double-stranded circular DNA genome of [approximately equal to]5 kb packaged within a capsid 45-50 nm in diameter and composed of 3 proteins: VP1, VP2, and VP3 (3).
Herpes viruses are double-stranded DNA viruses
that cause common infections in humans, including herpes, CMV, chickenpox, shingles, mono, measles, and Karposi Sarcoma.
Polyomaviruses (PyVs) are highly prevalent, small DNA viruses
, capable of persistence in the host.
One of the causes of oral lesions is a group of DNA viruses
, human papilloma viruses, which induce hyperplastic lesions in the oral soft tissue such as papillomas, warts, condylomata and focal epithelial hyperplasia.
Resemblances between these two double-stranded DNA viruses
, which infect very different hosts, suggest an evolutionary relationship not previously observed.