Dopa


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Related to Dopa: dopamine, DOPA decarboxylase

dopa

[′dō·pə]
(biochemistry)

Dopa

 

3,4-dihydroxyphenylalanine, C6H3(OH)2CH2CH(NH2)COOH, an amino acid.

In animals, dopa is one of the precursors in the chain of catecholamine biosynthesis. It is produced in tissues by the oxidation of tyrosine. In animals, plants, and some microorganisms, dopa is the first intermediate product in the synthesis of melanins. Healthy persons excrete from 50 to 55 μg of dopa daily with the urine; the amount increases in the presence of a neuroblastoma, a kind of malignant tumor. An inhibitor of dopa decarboxylase, a-methyldopa (Aldomet), is used in the treatment of parkinsonism and hypertension.

REFERENCES

Matlina, E. Sh., and V. V. Men’shikov. Klinicheskaia biokhimiia katekholaminov. Moscow, 1967.
Grollman, A. Klinicheskaia endokrinologiia i ee fiziologicheskie osnovy. Moscow, 1969. (Translated from English.)
References in periodicals archive ?
The same group and others have used the method to characterize the neurochemical profiles of dopamine-|3hydroxylase deficiency, DOPA decarboxylase deficiency, tyrosine hydroxylase deficiency, Menkes disease, and X-linked deficiencies of monoamine oxidase.
In PD patients, SPECT and PET studies have shown a progressive loss of DAT and VMAT2 and reduced dopa decarboxylase activity using [[.
2) The body methylates dopamine, dopa, 5-hydroxytryptophan, tyrosine, and other biochemicals as a temporary measure to prevent tissue damage.
The clinical component [of the study] failed to find any evidence that DOPA treatment is harmful or hastens progression of PD," he said.
Other culprits include the high blood pressure treatment methyl dopa and clonidine - a treatment for migraine and hot flushes.
Key to its adhesiveness is a family of unique proteins called mussel adhesive proteins, which contain a high concentration of the catecholic amino acid DOPA (dihydroxyphenylalanine).
They all rely on proteins that contain an amino acid called "Dopa," (identical to the Dopa used to treat Parkinson's disease), and have been studied extensively by Waite and his research group.