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The team then created mice in which the gene for ERBB2 was knocked out only in cardiomyocytes.
Statistical methods have been used to define a number of genomic regions of significant copy number alteration in serous-like tumors, including regions of focal amplification involving the MYC (v-myc avian myelocytomatosis viral oncogene homolog) oncogene, the ERBB2 (HER2) receptor tyrosine kinase gene, and CCNE1 (cyclin E1), which are each focally amplified in 23%-25% of cases (15).
Lung cancer: intragenic ERBB2 kinase mutations in tumours.
Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab.
8] Human genes: HPRT1, hypoxanthine phosphoribosyltransferase 1; HPRT1, hypoxanthine phosphori bosyltransferase 1; RPLPO, ribosomal protein, large, PO; ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; AR, androgen receptor; ERBB4, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4.
However, because the virtual karyotype is not quantitative, it only indicates lower abundance of 17p (including the centromere and a portion of the q arm), compared with the rest of 17q (including the ERBB2 locus).
6%) harbored alterations in RTKs such as ERBB2, FGFR2, and MET.
In these amplified and overexpressed cancers, the ERBB2 protooncogene appears to be a primary driver of cancer cell proliferation.
Approximately 18% to 20% of all breast carcinomas carry ERBB2 (HER2/ neu) mutations, while somatic TP53 mutations are found in 20% to 50% of tumors.
2], as well as 4-nonylphenol and the fluorotelomer alcohols, we observed up-regulation of trefoil factor 1, progesterone receptor, and PDZK1 and down-regulation of ERBB2 gene expression.
About 15%-25% of these cases show amplification of the ERBB2 gene [v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/ glioblastoma derived oncogene homolog (avian); also known as HER2 (human epidermal growth factor receptor 2)] (2).
ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.