biological half-life

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biological half-life

[¦bī·ə¦läj·ə·kəl ′haf ‚līf]
(physiology)
The time required by the body to eliminate half of the amount of an administered substance through normal channels of elimination.
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Collectively, these exposure decline results for short-term, long-term, and lifetime fish consumption advisory compliance are consistent with the long human elimination half-life of PCB-153 (15.
With little or no human data, the risk to a nursing infant is estimated by considering indication, duration of therapy, molecular weight, plasma protein binding, elimination half-life, presence of the drug in the systemic circulation, and the most common adverse effects observed in adults.
The plasma elimination half-life of a single dose ranges from 18 to 20 hours in young adults to approximately 36 hours in elderly patients.
Pharmacologically, amiodarone has high lipid solubility, a large volume of distribution, and an elimination half-life ranging from 40 to 60 days.
0-[infinity]], serum elimination half-life, time to reach peak serum concentration, elimination rate constant, and mean resident time did not change significantly.
Poor metabolizers have an 80% increase in drug exposure and twice the elimination half-life, compared with extensive metabolizers, placing them at increased of adverse drug reactions.
Methadone's analgesic effects last for 4-8 hours, but its elimination half-life is 8-59 hours.
In the case of zolpidem, maximum blood levels occur about 1 hour after ingestion and its elimination half-life is 2.
Its elimination half-life averages 24 to 36 hours at a steady state, but may range from 4 to 91 hours.
Tadalafil has a longer elimination half-life than sildenafil (17.
PEG-INTRON, recombinant interferon alfa-2b linked to a 12,000 dalton polyethylene glycol (PEG) molecule, is a once-weekly therapy designed to optimize the balance between antiviral activity and elimination half-life.

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