conveys epigenetic inheritance
during mitosis and meiosis; Cell 93:505;
Lamarck rises from his grave: Parental environment-induced epigenetic inheritance
in model organisms and humans.
The purpose of this article is to explain the basic science of transgenerational epigenetic inheritance
, highlighting particularly intriguing examples from human beings and rodent models, and to suggest that these discoveries require appropriate responses from Christian educators in science and from Christian communities in general.
New findings indicate that the role of genes and our understanding of inheritance are all the more complex, with RNA playing a greater role than expected, sections of DNA coding for more than one protein, overlapping genes, single genes being located on multiple chromosomes, and epigenetic inheritance
(Pearson, 2006; Pennisi, 2007; Flannery, 2010).
Azim Surani, who was not involved in this study, said "This elegant study on TRIM28 provides significant mechanisticinsights on how maternal factors in eggs ensure faithful epigenetic inheritance
that plays a critical role during development.
If the term epigenetic inheritance
is used comprehensively to include mitotic inheritance, then some of the mechanisms underlying phenotypic plasticity may be based on epigenesis.
The case for transgenerational epigenetic inheritance
This structured reference intended for a wide audience of students and researchers introduces epigenetics and epigenetic methods in 16 contributed chapters covering such topics as early life environment, murine models of transgenerational epigenetic inheritance
, centromeres and telomeres, histones (dosage and degradation), DNA methylation changes in cancer, and variant histones H2A and cancer development, among other topics.
These new biological arguments provide a modern context suggesting that Kammerer could be the actual discoverer of epigenetic inheritance
The remaining 23 invited papers explore the human, mosquito, and viral factors that contribute to the global spread and persistence of dengue; the possible roles of interlinked bistable networks, epigenetic inheritance
, and bet-hedging in bacteria; and the identification and localization of base J in the genome of kinetoplastids, the enzymes involved in J biosynthesis, and possible biological functions.
Today, the evidence for epigenetic inheritance
in plants and animals--from paramecia and yeast to humans and corn--is abundant (Jablonka and Lamb 1995).
The final class of arguments offered by Jablonka and Lamb is perhaps the most interesting, dealing as it does with interactions between the genetic (DNA) and epigenetic inheritance