Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase
activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls.
People with galactosemia, either classic galactosemia or epimerase
deficiency galactosemia, have genetic mutations that decrease their levels of the key enzymes (GALT and GALE) responsible for the metabolism of a common form of dietary sugar.
du Pont de Nemours and Company (Wilmington, DE) has patented an isolated nucleic acid fragment encoding a plant enzyme that catalyze steps in the biosynthesis of lysine, threonine, methionine, cysteine and isoleucine from aspartate, the enzyme a member selected from the group consisting of: dihydrodipicolinate reductase, diaminopimelate epimerase
, threonine synthase, threonine deaminase and S-adenosylmethionine synthetase.
Galactose is then further metabolized and is converted to glucose with the help of three enzymes present on the red blood cells: galactokinase, 1-phosphate uridyl transferase, and uridine diphosphoglucose 4 epimerase
MI is then converted in DCI by epimerase
in mammalian tissues.
Molecular characterization of a first human 3(alpha [right arrow] beta)-hydroxysteroid epimerase
Larner, "Decreased myoinositol to chiro-inositol (M/C) ratios and increased M/C epimerase
activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls," Endocrine Journal, vol.