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A hormone, thought to be produced by the kidneys, that regulates erythropoiesis, at least in higher vertebrates.



a hormone that stimulates the formation of erythrocytes in bone marrow. Characterized as a glycoprotein, erythropoietin has a carbohydrate content of 35 percent. It has a molecular weight of 30,000–40,000 and possesses antigenic properties. Erythropoietin is inactivated by neuraminidase, trypsin, chymotrypsin, and papain.

Erythropoietin was discovered by the French researchers F. Corneau and C. de Flandre in 1906 in rabbit serum that they tested after drawing blood. The hormone is found in low concentrations under normal physiological conditions, but the levels increase when the subject is in a state of hypoxia as a result of the loss of blood, a decrease in the oxygen content of the air, or various forms of anemia. Most scientists believe that erythropoietin is formed in the kidneys. When the hormone acts on stem cells in bone marrow, it causes their differentiation into cells of the erythroid series.


Fedorov, N. A., and M. G. Kakhetelidze. Eritropoetin. Moscow, 1973.
Normal’noe krovetvorenie i ego reguliatsiia. Moscow, 1976.
Gordon, A. S. Regulation of Hematopoiesis, vol. 1. New York [1970].


References in periodicals archive ?
Beta-endorphin, enkephalins, melanocyte stimulating hormone, thyroxin, thyro-tropin, vasopressin, aldosterone, renin, erythropoetin, growth hormone, insulin, glucagon, prolactin, parathyroid hormone, calcitonin, and gastrin have all been shown to increase during stress, though the exact significance of these elevations has not been worked out in all cases (Jemmott & Locke, 1984; Borysenko & Borysenko, 1982).
Yegorova was originally suspended after she tested positive for the banned hormone erythropoetin (EPO) following a meet in Paris on July 6.
The correlation between sTfR and bone marrow erythropoetic activity allows the use of sTfR for monitoring erythropoetin therapy, with sTfR increasing 4 weeks before the first increase of hemoglobin (7).
The Italian daily La Republica carried reports claiming the athletes took the banned oxygen boosting hormone erythropoetin (EPO) in 1992 and 1993.
Cholesterol testing and diet therapy only $452 Antihypertensive therapy to prevent stroke (age 45-64) 1932 Coronary artery bypass grafting 4295 Kidney transplant 9679 Adjuvant 5-FU/levamisole for Duke's C colonic cancer (Smith et al, 1993) 11725(#) Hospital hemodialysis 45148 Erythropoetin treatment for anemia in dialysis patients 111751
One additional promissing development is a genetically engineered drug called erythropoetin (EPO) that regenerates red blood cells.
Erythropoetin will also be valuable for surgical patients who are discharged slightly anemic because of the growing practice of avoiding transfusions whenever possible.
Erythropoietin, or its alternatives erythropoetin or erithropoyetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production.
Hinault's compatriot Laurent Jalabert was this week accused of taking the banned blood booster erythropoetin (EPO) on the scandal-hit 1998 Tour.
This factor, an heterodimer including one of the three subunit alpha 1, 2, 3 and a beta subunit, activates the transcription of genes coding for proteins mediating the adaptive response to hypoxia, such as erythropoetin and some enzymes of the glycolytic pathway (3), (4).
However, in a meta-analysis with more than 13,000 cancer patients erythropoetin treatment was found to increase mortality by 17% and should therefore be used extremely carefully (Bohlius et al.
In of 2007, the RPN scope of practice was further increased to include administration of Erythropoetin IV push during hemodialysis.