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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
Estrogens (brand names such as Premarin [R], Ogen [R], Estrace [R], Estraderm [R], Estratab [R], Prempro [R] and others)
Perimenstrual migraine: effect of Estraderm TTS and the value of contingent negative variation and exteroceptive temporalis muscle suppression test.
A further comparison was made between the Immulite E2 assay and the Coatria-II assay in five patients receiving 2 mg of Divina[R] (E2 valerate; Innothera, Arcueil, France), in one patient receiving 2 mg of oral Progynova[R] (E2 valerate; Schering, Lys-les-Lannoy, France), in 23 patients with a cream application of Oestrogel, and in 11 patients with Estraderm patches.