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Estradiol
(redirected from Estraderm)

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estradiol [‚es·trə′dī‚ȯl]
(biochemistry)
C18H24O2An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.
Estradiol 

C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).
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They include the three estrogens (estradiol, estriol, and estrone in products such as Estrace, Vivelle, Climara, and Estraderm patches) and micronized progesterone (such as Prometrium and Crinone vaginal gel).
Endometriosis at menopause by A Friend Indeed
A detailing aid for Climara (estradiol transdermal system), which was identified through routine monitoring, was cited for false and misleading comparative information regarding the Alora, Vivelle and Estraderm products, a misleading headline implying superiority without adequate clinical studies, and rele-gation of side effects and contraindications to small print at the bottom on the back.
DDMAC UNTITLED LETTERS by Warning Letter Bulletin
A March 26, 1997 untitled letter said a campaign promoting Forest=s Climara over Estraderm, made by Ciba Geneva Pharma-ceuticals, was misleading and lacked fair balance (Doc.
HUMAN DRUGS...and follows with another to Forest Labs by Warning Letter Bulletin
 
 
 
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