Estradiol

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Related to Estring: Vagifem, Femring

estradiol

[‚es·trə′dī‚ȯl]
(biochemistry)
C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.

Estradiol

 

C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
Estring provides an alternative that contains a very low dose of estrogen applied directly to the tissues of the vagina and urinary tract.
In addition, the Canadian Competition Bureau's decision includes Pfizer's commitment to amend an existing distribution agreement in Canada related to Estring.
Since 2001, women in developed countries have successfully used vaginal rings, such as the NuvaRing, ESTRING and Femring, for birth control and hormonal therapy.
For stress UI, treatment options include topical estrogen or Estring (but not oral estrogen), [alpha]-adrenergic agents such as pseudoephedrine, and imipramine, which may be particularly helpful for combined urge and stress incontinence.
Cost/day is based on the average wholesale price of Estring in the 2002 Red Book.
A similar device, Estring, is approved for treating urogenital symptoms associated with postmenopausal atrophy of the vagina or lower urinary tract.
In the first quarter, Pharmacia & Upjohn also launched Cabaser (Parkinson's disease) in Europe, and Dostinex (hyperprolactinemia) and Estring (estrogen replacement therapy for postmenopausal women) in the United States.
Best Overall Campaign in Business Press to Pfizer and Euro RSCG Life LM&P for Estring "Below the Belt" campaign, with an honorable mention going to Wyeth and Grey Healthcare Group for ReFacto "Shadow" ad
launch of Estring, for symptoms of urogenital aging
14 /PRNewswire/ -- Pharmacia & Upjohn (NYSE: PNU) announced today that the Estring Vaginal Ring (estradiol vaginal ring) is now available by prescription in the United States.