exonuclease

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exonuclease

[¦ek·sō′nü·klē‚ās]
(biochemistry)
Any of a group of enzymes which catalyze hydrolysis of single nucleotide residues from the end of a deoxyribonucleic acid chain.
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However, if the DNA polymerase used has an associated 5'-3' exonuclease activity (e.
The associated 5'-3' exonuclease activity of the DNA polymerase makes possible the synthesis of extension products derived from upstream primers even in the presence of downstream primers.
For example, degradation of downstream primer extension products might not be complete at each cycle because of premature termination of primer extension or <100% efficiency of the polymerase 5'-3' exonuclease activity.