FUDR


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FUDR

(pharmacology)
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Randomized studies of hepatic artery infusion vs systemic therapy in patients with unresectable liver metastases Response rate Median survival Site (reference) Regimen (%) (months) MSKCC (16) HAI-FUDR 52 18 Sys-FUDR 20 11 NCI (17) HAI-FUDR 62 17 Sys-FUDR 17 12 NCOG (18) HAI-FUDR 42 17 Sys-FUDR 10 16 Mayo (19) HAI-FUDR 48 13 Sys-5FU 21 11 France (20) HAI-FUDR 21 11 Sys-5FU 9 11 MSKCC indicates Memorial Sloan-Kettering Cancer Center; NCI, National Cancer Institute; NCOG, Northern California Oncology Group; Mayo, Mayo Clinic; HAI, hepatic artery infusion; FUDR, floxuridine; sys-5FU, systemic 5-fluorouracil.
Over the past three years, FDA marketing clearance has been obtained for the pump for administration of the chemotherapy drug, FUDR, and for administration of morphine for both malignant and benign pain management.
s SIR-Spheres[R] microspheres are indicated for the treatment of non-resectable metastatic colorectal cancer in combination with intra-arterial FUDR chemotherapy.