factor X

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Related to Factor Xa: factor IIa

factor X

[′fak·tər ′ten]
(biochemistry)
References in periodicals archive ?
Portola is developing andexanet alfa as a universal antidote for patients anticoagulated with an oral or injectable Factor Xa inhibitor who experience a serious uncontrolled or life-threatening bleeding event or who require urgent or emergency surgery.
As with the other factor Xa inhibitors, therapeutic monitoring is not required during routine treatment with edoxaban.
An often overlooked pharmacokinetic property of dabigatran and the other factor Xa inhibitors is the effect of an efflux pump on the luminal aspect of the gastrointestinal mucosa.
Buller said he believed was real and due to the effect of warfarin on clotting factor VII, and is something that has also been seen in the trials testing the other new factor Xa inhibitors.
Subcutaneous heparin, LMWHs, fondaparinux and direct factor Xa inhibitors have all been approved for the prophylaxis of DVT, particularly in hospitalised patients and others at high risk.
Inhibe el factor Xa con un Ki de 0,4 nM, tiene vida media de 6 a 10 horas y es eliminado por via renal y digestiva.
Rivaroxaban is an oral direct factor Xa inhibitor with a competitive and reversible binding effect to factor Xa.
Thrombin converts fibrinogen to fibrin, and factor Xa converts the zymogen prothrombin to thrombin.
Dicho enlace conduce a la inhibicion acelerada del factor Xa, lo cual contribuye al gran potencial antitrombotico del medicamento [2, 3].
STOCKHOLM -- Use of the oral factor Xa inhibitor apixaban slashed the risk of stroke or systemic embolism by more than half, compared with daily aspirin, in patients with atrial fibrillation who were candidates for but unable to take warfarin, in the phase III AVERROES trial.
Betrixaban belongs to a new class of blood-clot preventers called factor Xa inhibitors that are being developed by several drugmakers, including German drugmakers Bayer AG and Boehringer Ingelheim GmbH, and New York-based Bristol-Myers Squibb Co.