Fas protein

Fas protein

[¦ef¦ā′es ‚prō‚tēn]
(cell and molecular biology)
A cell-surface protein receptor expressed on essentially all cells of the body that when bound to its ligand (FasL) signals a caspase cascade, ultimately resulting in apoptosis (programmed cell death).
References in periodicals archive ?
The results are consistent with the study in rats, as niacin administration relieved the increased ACC and FAS protein due to chronic renal failure in kidney (Cho et al.
The Fas receptor is located on the surface of the cell and is triggered by a ligand, which is a molecule that when produced fits into a complex receptor site on the Fas protein, like a key fits into a lock.
Pursuing that possibility, their experiments would piece together the pathway of the genes to discover that the lupus mice had a malfunctioning Fas protein that prevented their bone marrow mesenchymal stem cells from releasing a molecule needed for normal differentiation/bone formation.
The increasing expression of Fas protein on the cells' surface induces interferon and TNF[alpha], and also activation of lymphocytes.
Treating the 3T3-L1 cells with 15 [mico]g/ml 6-gingerol decreased the FAS protein levels by 26.
Moreover, additional studies revealed that FAS protein expression was three times higher in uterine fibroid samples compared to normal myometrial tissue (muscle tissue that forms the uterine wall).
To further investigate the potential role of ficolins in the preeclamptic trophoblasts, we demonstrated the strong expression of apoptotic protein marker Fas protein, and also the coexpression of both ficolins and Fas in the syncytiotrophoblasts from established preeclamptic pregnancies (n = 5; Fig.
After the confirmation of the activated caspase-3, a marker of apoptosis development, and the elevated levels of active caspase-8 and Fas protein, we did not observe increased levels of active caspase-9 or released cytochrome c in SHS-exposed rat hearts.
Sure enough, the genetically engineered mice appeared to manufacture healthy amounts of the normal Fas protein.
Therefore, Fas protein play an important role in the trait expression associated with fat synthesis (Kim et al.
Many liver diseases are characterized by apoptosis, which is mediated by the Fas protein.