Pursuing that possibility, their experiments would piece together the pathway of the genes to discover that the lupus mice had a malfunctioning Fas protein
that prevented their bone marrow mesenchymal stem cells from releasing a molecule needed for normal differentiation/bone formation.
Treating the 3T3-L1 cells with 15 [mico]g/ml 6-gingerol decreased the FAS protein
levels by 26.
Moreover, additional studies revealed that FAS protein
expression was three times higher in uterine fibroid samples compared to normal myometrial tissue (muscle tissue that forms the uterine wall).
To further investigate the potential role of ficolins in the preeclamptic trophoblasts, we demonstrated the strong expression of apoptotic protein marker Fas protein
, and also the coexpression of both ficolins and Fas in the syncytiotrophoblasts from established preeclamptic pregnancies (n = 5; Fig.
After the confirmation of the activated caspase-3, a marker of apoptosis development, and the elevated levels of active caspase-8 and Fas protein
, we did not observe increased levels of active caspase-9 or released cytochrome c in SHS-exposed rat hearts.
Sure enough, the genetically engineered mice appeared to manufacture healthy amounts of the normal Fas protein
Changes in Bcl-2 and Fas protein
expression are showed in Fig.
Many liver diseases are characterized by apoptosis, which is mediated by the Fas protein
Using the ARIAD system, it may be possible to genetically modify the cancer-fighting cells so that they produce a FAS protein
that responds to an ARIAD small-molecule drug.
However, after 24 h [beta]-sitosterol supplementation of MCF-7 cells, there was a 30% increase in Fas protein
level compared to MCF-7 cells supplemented with cholesterol or CD vehicle control (Fig.
When Fas proteins
are activated, they in turn activate and mobilize other protein families involved in apoptosis, such as the Bcl-2 family.