Visterra has also applied its Hierotope platform to develop novel modifications to the Fc region
of an antibody, to enhance half-life by as much as ten-fold while maintaining and often improving effector function.
What is unique about this drug is that it is the only Fc-free, PEGylated anti-TNF Without this Fc region
, it cannot be actively transported by the FcRn receptor on the placenta and, thus, results in minimal placental transmission.
This proprietary approach is associated with specific mutations that are present in the Fc region
of the antibody, noted Rangesa.
In this study we aimed to fuse the ctla-4 gene encoding the extracellular domain of CTLA-4 molecule with igg1 gene encoding Fc region
of human IgG.
Cimzia is a small antibody, with a mass of about 40kDa (kilodaltons); therefore, it lacks the ability to cross-link, and it also lacks an Fc region
Differences in glycosylation (generally present in the Fc region
of the mAb) would be expected to impact mAb-Fc interaction with the FcyRIIIa.
of IgY mediates most biological effector functions, such as complement fixation, anaphylactic reactions and opsonization, whereas the Fab region contains the antigen binding sites (DAVISON et al.
NHance achieves this through 2 specific mutations in the antibody Fc region
(at His433 and Asn434), resulting in an improved affinity of antibody binding to the neonatal Fc receptor at acidic pH.
Rheumatoid factor is an autoantibody targeting the Fc region
of IgG antibodies.
Staphylococcus aureus is the most common bacterial cell that is used as a carrier because Protein A expressed on the surface of the bacterium naturally binds to the Fc region
of immunoglobulin, allowing for the binding of the antibody to the bacterial cell while leaving the Fab region of the immunoglobulin free to bind to the antigen.
A commercially available recombinant chimeric extracellular sP conjugated with the Fc region
(rhP/Fc) exhibited better performance in terms of stability and affinity toward [CD34.
A sequence encoding amino acids 301-437 of the Fc region
of the mouse IgE molecule was genetically fused to PE40-a truncated form of PE lacking the cell binding domain.