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Fc region

   Also found in: Wikipedia 0.01 sec.
Fc region [¦ef′sē ‚rē·jən]
(immunology)
Region of an antibody molecule that binds to antibody receptors on the surface of cells such as macrophages and mast cells, and to complement protein; Fcis derived from the term crystallizable fragment.


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They showed, for the first time, that the Fc region present in conventional anti-TNFs is not required for activity in rheumatoid arthritis," commented Professor Edward Keystone, Professor of Medicine, University of Toronto, Canada.
A sequence encoding amino acids 301-437 of the Fc region of the mouse IgE molecule was genetically fused to PE40-a truncated form of PE lacking the cell binding domain.
I look forward to bringing insights and experience gained from my work with the Fc region to bear on the advancement of Xencor's pipeline of enhanced antibodies.
 
 
 
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