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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
dose of 17 beta-estradiol (a natural form of estrogen) in a thin, flexible once-weekly patch, FemPatch provides highly effective relief of vasomotor symptoms such as hot flashes and night sweats.
The Company's results of operations vary significantly from period to period and depend on, among other factors, the signing of new product development agreements and the timing of recognizing payment amounts specified thereunder, the timing of recognizing license fees and cost reimbursement payments made by pharmaceutical company licensees, the demand for its Nicotrol(R) patch (Pharmacia AB, Stockholm, Sweden), and the demand for and costs associated with the manufacture of the FemPatch system.
In clinical trials, FemPatch was well tolerated, with a low discontinuation rate of 2.
launched FemPatch, a transdermal estrogen replacement system, in the U.