thrombolytic drug

(redirected from Fibrinolytics)

thrombolytic drug

(thrŏm'bəlĭt`ĭk) or

clot-dissolving drug,

substance, such as streptokinase or tissue plasminogen activator (tPA), that causes the breakdown of blood clots (see thrombosisthrombosis
, obstruction of an artery or vein by a blood clot (thrombus). Arterial thrombosis is generally more serious because the supply of oxygen and nutrition to an area of the body is halted.
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) that obstruct the flow of blood through the vessels. Its uses include injection during or shortly after a heart attack or strokestroke,
destruction of brain tissue as a result of intracerebral hemorrhage or infarction caused by thrombosis (clotting) or embolus (obstruction in a blood vessel caused by clotted blood or other foreign matter circulating in the bloodstream); formerly called apoplexy.
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 (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
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) to prevent clots from blocking blood flow to the heart muscle or brain.
References in periodicals archive ?
Early use of intrapleural fibrinolytics in the management of postpneumonic empyema.
Looking at reasons for delays in administering fibrinolytics to patients with AMI at Steve Biko Academic Hospital, Meel and Gonsalves [9] convey the dismaying news that the majority of patients (67%) presenting to the capital's academic hospital did not receive fibrinolytic therapy at all.
The contract is for the supply of medicinal products - fibrinolytics.
In addition, fibrinolytics have been shown to offer no benefit, and in fact may be harmful to NSTEMI patients.
0b013e318284056a]) state that "The only laboratory result required in all patients before fibrinolytics therapy is initiated is a glucose determination; use of finger-stick measurement devices is acceptable.
While the best management strategy for complicated pneumonia continues to be debated, there's been increasing use of procedures, particularly chest tube placement with fibrinolytics such as tissue plasminogen activator and video-assisted thoracoscopic surgery.
Apart from treatment directed towards the causes, anticoagulants, fibrinolytics and surgical methods are being used.
Despite the proven benefits of quickly restoring blood flow to the heart muscle during a heart attack, 30% of STEMI patients do not receive any reperfusion therapy," neither fibrinolytics nor primary percutaneous coronary intervention (PCI), said Dr.
Mechanical intervention is indicated for patients in whom fibrinolytics are contraindicated, and for those who demonstrate poor response to local urokinase infusion or experience rapid neurological decline.
Furthermore, the perception by many casualty officers that administering fibrinolytics is 'not their responsibility' should be addressed.
The ACCP statement says that existing evidence is equally supportive of VATS, surgery, or fibrinolytics as acceptable approaches for managing complicated empyema.
4] in the first study describing the use of fibrinolytics in African children, describe the experience at Red Cross War Memorial Children's Hospital with intrapleural fibrinolytic therapy as first-line treatment in empyema.