Fibrocyte


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fibrocyte

[′fī·brə‚sīt]
(histology)

Fibrocyte

 

a connective-tissue cell in man and other vertebrates, a fibroblast that has reached its final stage of differentiation and is incapable of further division.

References in periodicals archive ?
Fibrogenic mediators in ALI may also represent useful biomarkers and include type III procollagen, myofibroblasts, fibrocytes, and proteoglycans (PGs; Table 3).
In comparison of A1, B1 and C1 all discs in group A and most of the disc (eight) in group C showed normal lamellar and wavy pattern of collagen / proteoglycan with abundant distribution of fibrocytes and chondrocytes in normal scattered manner as shown in Figure 1.
sup][40] In this monocyte to fibrocyte differentiation, monocytes first differentiate into M1 macrophages, the latter become M2 macrophages, and finally M2 macrophages give rise to fibrocytes.
The peripheral blood fibrocyte is a potent antigenpresenting cell capable of priming naive T cells in situ.
These studies clearly highlight the significant potential for Pentraxin-2 therapeutics in the treatment of liver fibrosis, a disease which is characterized by massive accumulation of extracellular matrix along with the undesirable activation of quiescent hepatic stellate cells and fibrocytes in the liver.
The poster presentation entitled "The Effects Of Recombinant Human Pentraxin-2, (PRM-151), On Circulating Fibrocytes In Idiopathic Pulmonary Fibrosis (IPF)" included clinical data from a completed Phase 1 study of PRM-151 that evaluated comprehensive safety endpoints and exploratory biomarker activity in healthy subjects and IPF patients.
The findings regarding the effects of PTX-2/SAP in the lung specific TGF1 transgenic mouse model expand on previous preclinical studies, in which Promedior investigators determined that PTX-2/SAP potently inhibited lung fibrosis in both acute bleomycin-induced pulmonary fibrosis models and chronic asthma models through an inhibition of pulmonary fibrocyte and pro-fibrotic (M2) macrophage activation and accumulation, associated with increased macrophage production of the regulatory cytokine IL-10.
Circulating fibrocytes correlate with bronchiolitis obliterans syndrome development after lung transplantation: A novel clinical biomarker.
The stroma of villi consists of fibrocytes and fibroblasts, often edematous.
AQP1 expression was observed by immunohisto-chemistry in the cochlea of Mongolian gerbil, specifically in type III and type IV fibrocytes, mesenchymal cells lining the bony otic capsule of the perilymphatic space, and fibrocytes in the spiral limbus.
Targets of these antibodies are stria vascularis, fibrocytes of the spiral ligament and supporting cells.
First of all, in the tops of lymphoid nodules, a large, almost 3-fold increase in the number of stromal cells (fibroblasts, fibrocytes, reticulocytes) drew the attention.

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