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fluorescent in situ hybridization |
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fluorescent in situ hybridization [flə¦res·ənt in¦sit‚chü ‚hī·brə·də′zā·shən] (genetics) A technique in which a deoxyribonucleic acid (DNA) probe is labeled with a fluorescent dye (that can be visualized under a fluorescent microscope) and then hybridized with target DNA, usually chromosome preparations on a microscopic slide. It is used to precisely map genes to a specific region of a chromosome in prepared karyotype, or can enumerate chromosomes, or can detect chromosomal deletions, translocations, or gene amplifications in cancer cells. Abbreviated FISH. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Donor age and the frequency of disomy for chromosomes 1,13,21 and structural abnormalities in human spermatozoa using multicolour fluorescence in-situ hybridisation. With regard to technology, hybridisation techniques tend to be the major technologies utilised in the field of pharmacogenomics, and fluorescence in-situ hybridisation (FISH) continues to be widely used due to its ability to detect a variety of chromosomal and genetic aberrations such as molecular translocation deletions specific to each entity of haematological malignancies in a single non-dividing interphase cell. |
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