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fluorescent in situ hybridization

   Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson 0.06 sec.
fluorescent in situ hybridization [flə¦res·ənt in¦sit‚chü ‚hī·brə·də′zā·shən]
(genetics)
A technique in which a deoxyribonucleic acid (DNA) probe is labeled with a fluorescent dye (that can be visualized under a fluorescent microscope) and then hybridized with target DNA, usually chromosome preparations on a microscopic slide. It is used to precisely map genes to a specific region of a chromosome in prepared karyotype, or can enumerate chromosomes, or can detect chromosomal deletions, translocations, or gene amplifications in cancer cells. Abbreviated FISH.


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6,7) Diagnosis is confirmed by fluorescent in situ hybridization (FISH) examination with a chromosome 22 library.
Partial tetrasomy of chromosome 22: genetic and surgical implications ... by Goncalves, Tania M.L. / Ear, Nose and Throat Journal
Jowett T, Yan YL Double fluorescent in situ hybridization to zebrafish embryos.
Developmental toxicology of cadmium in living embryos of a stable ... by Krone, Patrick H. / Environmental Health Perspectives
The presentations will address Immunicon's cellular analysis and molecular techniques for interrogating circulating tumor cells for protein targets associated with cancer therapeutics, chromosomal abnormalities and over-expression of cancer-specific genes through fluorescent in situ hybridization (FISH) testing, the next generation of Immunicon's CellTracks(R) technology, as well as the EasyCount(TM) System for rapid, accurate cell counting applications in the life science research market.
Immunicon Corporation to Present at ISAC XXIII International Congress by Business Wire
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