founder effect


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founder effect

[′fau̇n·dər i‚fekt]
(genetics)
The overrepresentation of a specific allele at one or more loci in a new population that arises from a small number of individuals whose small gene pool may be unrepresentative of the parental population initially or as a result of the ensuing genetic drift.
References in periodicals archive ?
glacial refugia) through founder effects and bottlenecks as a result of multiple stepwise colonization events (Hewitt, 1996; Widmer and Lexer, 2001; Jim6nez et al.
Future research also could be directed toward founder effects beyond the kind of malfeasance considered here.
1] may be reporting the true frequency (if Finland avoided the founder effect of this mutation in Europe), all samples that tested as normal should have been confirmed by an alternative DNA assay to rule out the occurrence of false-negative results.
Interestingly, with respect to neurodegenerative disease, there is some evidence for a founder effect for Huntingtons disease in SA, possibly arising from an early Dutch settler, since there is a common haplotype indicative of a European origin.
So does such a founder effect play a similarly significant effect in the dispersal and differentiation of languages?
A founder effect is a term from biology that refers to when a small group breaks off from a larger group.
3,4] A founder effect results when a small subset of a large population establishes a new population.
However, she explains, amongst these, no founder effect mutation was found, i.
For both ENG and ACVRL1, many mutations have been reported by independent groups in different countries, in most cases without any evidence of a founder effect, which could be suspected only in a limited number of cases.
It was postulated at the time that this increased incidence could be attributed to a founder effect.
Evidence from our research laboratory suggests that this SA SCA7 haplotype may be present in a SCA7 family native to northern Namibia, and a Zambian SCA7 patient, supporting the hypothesis that the founder effect may extend geographically into areas north of SA.