fragile site

(redirected from Fragile sites)
Also found in: Medical, Wikipedia.

fragile site

[′fraj·əl ¦sīt]
(genetics)
The chromosomal position of a deoxyribonucleic acid sequence predisposed to spontaneous or induced breakage; sometimes contains short repetitive sequences.
References in periodicals archive ?
We have previously shown that oncogene activation (and therefore cell transformation) is associated with DDR activation at fragile sites (Di Micco, Nature 2006).
The findings that miRNAs were frequently located at cancer-associated genomic regions, including fragile sites, prompted these investigators to propose that miRNA genes were a new class of genes involved in human tumorigenesis (2).
8] Cytogenetic detection of FRAXA is not reliable as a diagnostic test for FXS as it cannot differentiate between this and other fragile sites, such as FRAXD, FRAXE and FRAXF, and it is costly.
Key words: dog, mammary tumors, cytogenetic, fragile sites.
Possible correlations between chromosome breakpoints other than 9 and 22 in these Ph variant tranlocations, and recent updates for the map locations of consistent cancer breakpoints, fragile sites, and oncogenes are discussed.
The underlying DNA structure of fragile sites appears to make them particularly prone to breakage and hence to being jettisoned from the cancer genome.
Population cytogenetics of folate-sensitive fragile sites.
ABSTRACT : An investigation to determine frequency and distribution of folate sensitive chromosomal fragile sites was carried out in a Pakistani breed of Lohi sheep to uncover fragile site phenomena.
The 22 articles in the 2007 edition of the annual series summarize recent developments in understanding cell cycle regulation of DNA replication, chromosome fragile sites, the biology of Candida albicans, and transport of sequence-specific RNA interference information between cells.
The final tier includes subtelomeric FISH; comparative genomic hybridization; screening for folate-sensitive fragile sites, 7-dehydro-cholesterol, and the UBE3A gene; and an extended metabolic work-up.
Known weak links in DNA chains are often broken in tumor cells, suggesting that such fragile sites on chromosomes may foster a variety of cancers (154: 317).
And he has taken every caution in the book not to include fragile sites.