fragile site

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fragile site

[′fraj·əl ¦sīt]
(genetics)
The chromosomal position of a deoxyribonucleic acid sequence predisposed to spontaneous or induced breakage; sometimes contains short repetitive sequences.
References in periodicals archive ?
Based onSeralini [16]and Dryginet al, [17], the GM food may lead to chromosome fragile sites in general and may lead to cancer development.
rDNA array boundaries) are DNA break fragile sites, which attract DNA breaks during sexual reproduction.
Human micro-RNA genes are frequently located at fragile sites and genomic regions involved in cancers.
Chromosomal fragile sites expressed through an increased frequency in gaps and breaks are identified, as well as a presence of conservation of fragile sites throughout evolution [13, 14].
8] Cytogenetic detection of FRAXA is not reliable as a diagnostic test for FXS as it cannot differentiate between this and other fragile sites, such as FRAXD, FRAXE and FRAXF, and it is costly.
Key words: dog, mammary tumors, cytogenetic, fragile sites.
A Study to compare the extent of geno-environmental interaction expressed as fragile sites was carried out in British Suffolk and Pakistani Lohi breeds of sheep (Ovis aries).
Possible correlations between chromosome breakpoints other than 9 and 22 in these Ph variant tranlocations, and recent updates for the map locations of consistent cancer breakpoints, fragile sites, and oncogenes are discussed.
The underlying DNA structure of fragile sites appears to make them particularly prone to breakage and hence to being jettisoned from the cancer genome.
Population cytogenetics of folate-sensitive fragile sites.
More people than ever are landing at fragile sites, with light aircraft, helicopters and all-terrain vehicles increasingly used for greater access; while in the past two seasons, 'fly-sail' operations have begun.
ABSTRACT : An investigation to determine frequency and distribution of folate sensitive chromosomal fragile sites was carried out in a Pakistani breed of Lohi sheep to uncover fragile site phenomena.