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frameshift mutation
(redirected from Frame shift)

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frameshift mutation [¦frām‚shift myü′tā·shən]
(genetics)
The addition or deletion of nucleotides to anexon in numbers other than three, which shifts the translation reading frame so a new set of codons beyond the point of abnormality in the messenger ribonucleic acid is read. Also known as phase-shift mutation.
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A frame shift mutation occur when there are too few or too many DNA building blocks, or nucleotides, in a genetic sequence, throwing off the ability of a gene to produce proteins.
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As the fetus grows, the pregnant woman''s weight inevitably increases and her frame shifts to accommodate the space in which the baby resides.
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