frameshift mutation

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frameshift mutation

[¦frām‚shift myü′tā·shən]
(genetics)
The addition or deletion of nucleotides to anexon in numbers other than three, which shifts the translation reading frame so a new set of codons beyond the point of abnormality in the messenger ribonucleic acid is read. Also known as phase-shift mutation.
References in periodicals archive ?
In addition, adriamycin can also induce frameshift and/or base-substitution mutations in prokaryotic (McCann et al.
sup][8] However, in our patients, the mutations were all small lesions, including nonsense and frameshift mutations, which could count for 8.
Three novel single base pair deletions resulting in frameshift mutations (c.
All 8 affected patients, presenting at least one frameshift or missense mutation, had heart diseases and ocular symptoms.
Adaptive reversion of a frameshift mutation in Escherichia coli.
Point mutations in PMP22 are rarely reported, although a variety of mutation types, including missense, nonsense, frameshift, and splicing mutations, have been mentioned.
Expect an with plenty a spot technology Here's just a few of the highlights to watch out for day by day: | SIRF17 officially launches on August 3 with Frameshift, a coproduction between Australian and Korean performance groups.
A form of albinism in cattle is caused by a tyrosinase frameshift mutation.
Causative mutations are loss-of-function mutations:131 approximately 65% are out-of-frame deletions of one or more complete exons; 5 - 10% are duplications; and the remainder are nonsense, splice site or frameshift mutations; missense mutations are rare.
The latter may involve a frameshift and affect transcriptional activity, especially for some critical codons.
Three main genetic variants [2 single-nucleotide polymorphisms (encoding the Arg702Trp and Gly908Arg substitutions) and a frameshift polymorphism (Leu1007fsinsC)] represent 82% of the variation in the NOD2 gene associated with Crohn disease; however, these variants are not associated with ulcerative colitis.
This strain type contains the genes for binary toxin and has an 18-bp deletion and a frameshift mutation in tcdC hypothesized to result in deregulated expression of toxins A and B.