glucokinase

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glucokinase

[¦glü·kō′kī‚nās]
(biochemistry)
An enzyme that catalyzes the phosphorylation ofD-glucose to glucose-6-phosphate.
References in periodicals archive ?
GCK is a novel and direct physiologic target of the Bad BH3 domain in [beta]-cells and genetic evidence combined with the pharmacological activity of novel stapled Bad BH3 peptides indicates that phosphorylation within the BH3 domain drives the metabolic function of Bad and serves as a physiologic switch between its apoptotic and metabolic effects [93].
Caption: Figure 2: Hepatic protein content and activity levels of GCK (panels (a) and (b), resp.
1c] in patients with GCK MODY isn't affected by treatment with insulin or oral hypoglycemic agents (Diabetologica 2014;57:54-6).
However, among more than 61,000 unrelated individuals who have participated in various large-scale gene-sequencing projects under the umbrella of the Exome Aggregation Consortium, GCK mutation rates were higher, ranging from 2.
Variants Nearest gene Full gene name rs11708067 ADCY5 Adenylate cyclase 5 rs2191349 DGKB/TMEM195 Diacylglycerol kinase, beta 90kDa --transmembrane protein 195 rs4607517 GCK Glucokinase (hexokinase 4) rs780094 GCKR Glucokinase (hexokinase 4) regulator rs1387153, MTNR1B Melatonin rs10830963 receptor 1B rs340874 PROX1 Prospero homeobox 1 Variants OR T2D Study type (a) rs11708067 1.
7) In this study we propose a diagnostic classification in 5 categories of the entities presenting with glomerular cysts (Table 1): type I, PKD presenting as a GCK variant of autosomal recessive polycystic kidney disease (ARPKD)/ADPKD (with or without liver disease); type II, hereditary GCK synonymous with GCKD.
Mutation in GCK and HNF-1 alpha explain the majority of cases with clinical diagnosis of MODY in Spain.
GCK S-1 Beauty Digital es una plancha perfecta para todo tipo de peinados.
The GCK Scholarship exemplifies Gwendolyn's ideals and pays tribute to her, by allowing the principles to which she committed her life to live on.
The activating mutations seen in GCK are inherited in an autosomal dominant manner.
Dinner Committee members included: Linda Christensen, Tishman Construction Corporation; Christine Flaherty, STV; Lina Gottessman, Alms Metal & Marble Services; Kay Lee, SimplexGrinnell; Connie DeLaiglei PANYNJ; Gwendolyn Colbert Kushner, GCK Consulting; Barbara Armand, Armand Corporation.