Transferase

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transferase

[′tranz·fə‚rās]
(biochemistry)
Any of various enzymes that catalyze the transfer of a chemical group from one molecule to another.

Transferase

 

any of a class of enzymes that catalyze the transfer of a chemical group from one compound (the donor) to another (the acceptor). Transferases are common in plant and animal tissues, as well as in microorganisms. They play a leading role in intermediary metabolism, participating in the transformations of carbohydrates, amino acids, nucleic acids, lipids, and other biologically important compounds.

The transferase class includes more than 450 enzymes, divided by the chemical nature of the group being transferred into subclasses. Examples include the subclasses that catalyze the transfer of single-carbon groups (methyltransferases), glycosyl groups (glycosyltransferases), nitrogen-bearing groups (aminotransferases, or transaminases), and phosphate groups (phosphotransferases). The transferases of the various subclasses have different coenzymes.

The mechanism of the catalytic action of the transferases studied to date includes the formation of an intermediate made up of the enzyme and group being transferred. For example, in the transfer of the acetyl radical (CH3CO—), an acetylated enzyme is formed in the first stage of the reaction, followed by the transfer of the radical to the acceptor and the liberation of the enzyme. The names of transferases are formed according to the sequence dononacceptor-transferred group-transferase. For example, the enzyme that catalyzes the transfer of the phosphate group from adenosinetriphosphate (ATP) to creatine is called ATP:creatine-phosphotransferase. Several transferases have been obtained in crystalline form.

REFERENCES

Nomenklatura fermentov. Moscow, 1966. (Translated from English.)
Kretovich, V. L. Vvedenie v enzimologiiu, 2nd ed. Moscow, 1974.

V. V. ZUEVSKII

References in periodicals archive ?
2% of the 47,092 eligible participants) with above-normal values; 55 IU/L in men and 38 IU/L in women for GGT (Schumann et al.
CDT, GGT ve MCV gibi belirtecler ise alkol kullanim miktari, kullanim suresi ve agir icicilerin saptanmasi gibi durumlarda bize daha uzunlamasina islevsel bilgi saglayabilmektedir.
020) (a) Due to a wide 95% CI the preanalytical SDs (excluding between- venipuncture) for GGT measured in SST tubes, magnesium measured in RST tubes, and for sodium measured in both RST and SST tubes are not shown.
The mean values of liver enzymes, for female/ male subjects in control group, AST; ALT and GGT respectively, were; 16.
The only thing of note was that the GGT kept rising until discharge.
Leukocyte, eosinophil, gamma globulin, and GGT values were higher in parasitized animals than in controls (p < 0.
Assim, niveis de GGT podem estar aumentados em neonatos apos o consumo de colostro, fato que pode servir de marcador da ingestao de colostro, principalmente em animais recem-nascidos (GONZALEZ; SILVA, 2003).
RR-R25 RST-14F 56-kDa gene (Orientia tsutsugamushi) RST-6R OMP3 com-1 (Coxiella burnetii) OMP4 Primer Sequence (5' [right arrow] 3') RR-F8 GGC GGY GCA TTA CTT GGT TCT CAA TTC GC RR-R12 GTT TTC CSC CTA TTA CAA CTG TTT GAG T RR-F1 AAA ATG GTT GCT GAG CTT GAA AAT CCT TT RR-R2 ACT TTC AAA CCA CCA CGT AAT CTA TTG AC RR-F22 ATG GTR TAT GGG CWA AAC CTT TCT ATA RR-R25 TAG MMT CGA AGA AGT AAC GCT GAC TTT RST-14F CCA TTT GGT GGT ACA TTA GCT GCA GGT RST-6R TCA CGA TCA GCT ATA CTT ATA GGC A OMP3 GAA GCG CAA CAA GAA GAA CAC OMP4 TTG GAA GTT ATC ACG CAG TTG Primer Amplicon size, bp RR-F8 304 RR-R12 RR-F1 191 RR-R2 RR-F22 330 RR-R25 RST-14F 233 RST-6R OMP3 438 OMP4 * groEL, 60-kDa heat-shock protein; ompB, outer membrane protein B; com-1, 27-kDa outer membrane protein.
Sensitivity among women was 34% for the EDAC and 23% for the GGT Specificity was 89% among men for the EDAC and 92% with the GGT.