Transferase

(redirected from GGT)
Also found in: Dictionary, Thesaurus, Medical, Acronyms.

transferase

[′tranz·fə‚rās]
(biochemistry)
Any of various enzymes that catalyze the transfer of a chemical group from one molecule to another.

Transferase

 

any of a class of enzymes that catalyze the transfer of a chemical group from one compound (the donor) to another (the acceptor). Transferases are common in plant and animal tissues, as well as in microorganisms. They play a leading role in intermediary metabolism, participating in the transformations of carbohydrates, amino acids, nucleic acids, lipids, and other biologically important compounds.

The transferase class includes more than 450 enzymes, divided by the chemical nature of the group being transferred into subclasses. Examples include the subclasses that catalyze the transfer of single-carbon groups (methyltransferases), glycosyl groups (glycosyltransferases), nitrogen-bearing groups (aminotransferases, or transaminases), and phosphate groups (phosphotransferases). The transferases of the various subclasses have different coenzymes.

The mechanism of the catalytic action of the transferases studied to date includes the formation of an intermediate made up of the enzyme and group being transferred. For example, in the transfer of the acetyl radical (CH3CO—), an acetylated enzyme is formed in the first stage of the reaction, followed by the transfer of the radical to the acceptor and the liberation of the enzyme. The names of transferases are formed according to the sequence dononacceptor-transferred group-transferase. For example, the enzyme that catalyzes the transfer of the phosphate group from adenosinetriphosphate (ATP) to creatine is called ATP:creatine-phosphotransferase. Several transferases have been obtained in crystalline form.

REFERENCES

Nomenklatura fermentov. Moscow, 1966. (Translated from English.)
Kretovich, V. L. Vvedenie v enzimologiiu, 2nd ed. Moscow, 1974.

V. V. ZUEVSKII

References in periodicals archive ?
We performed a retrospective study in the American Hospital, Tirana, Albania during the period (2013-2014) to give a representation of these correlations in the Albanian population and to propose a limit of alcohol amount that causes GGT changes.
Both Alk-Phos and GGT distributions were right-skewed and the median value of the two biomarkers was 89 UI/L and 20 UI/L, respectively (Figure 1).
sup][24] Previous studies proved that GGT and ALP were also closely related to severity and adverse outcome of chronic heart failure,[sup][17],[23] which was not significant in our study.
In conclusion, it was confirmed that there is an increase in liver cirrhosis in the following general characteristics and biochemical factors: increase of age, increase of GGT, decrease of albumin, increase of the total bilirubin, and growth of INR (International Normalized Ratio).
In our study there was high level of change of AST, ALT & GGT whereas level of ALP remain minimally changed with exception of minimal number of cases, all the values returned to normal at the follow-up after 3 weeks.
O aumento da GGT pode ocorrer quando ha lesao hepatica aguda, provocando aumento serico imediato na maioria das especies animais (40), possivelmente em decorrencia da liberacao de fragmentos de membrana celular devido a acao detergente dos acidos biliares que nao foram excretados normalmente pelos ductos biliares no intestino.
A more recent study (1) compared CDT, MCV, AST, ALT, GGT and sialic acid (SA) in subjects which had declared themselves recently abstinent from alcohol consumption.
In this study we compared sensitivity, specificity and diagnostic efficiency of serum Sialic acid with other traditional markers like AST (Aspartate amino transaminase), ALT (Alanine amino transaminase), GGT (Gamma Glutamyl Transferase), as a marker of alcohol abuse.
In a large population-based survey, PFOA but not PFOS was associated with both transaminase and GGT levels (Lin et al.
Urinary GGT levels were measured by GTSL method and urinary creatinine levels were measured using the JAFFE reaction and no adjustments were done for daily creatinine variations.
However, few epidemiological studies have explored the independent relationship between CKD and GGT.