EuroGIOPS was an 18-month, open-label, phase III clinical trial in which 92 men with GIOP were randomized to teriparatide or risedronate.
The 2010 update of the American College of Rheumatology guidelines for the prevention and treatment of GIOP recommend bisphosphonates but not teri- paratide for older adults at high risk of fracture who are taking less than 5 mg/day of prednisone for less than 1 month (Arthritis Care Res.
For example, what's the best management strategy in lupus patients and others who may need to be on systemic steroids for a decade or more, given that teriparatide is only FDA approved for 2 years of daily use and the clinical trials of bisphosphonates for GIOPS were only 1 or 2 years long (J.
The goal of prevention or treatment of GIOP is to reduce the risk of osteoporotic fracture.
This synthetic hormonal agent inhibits bone resorption and has been studied to a limited extent in the treatment of GIOP.
Data from the only randomized, controlled clinical trial of estrogen replacement therapy in GIOP indicate that after 2 years of treatment with either transdermal estradiol, 50 [micro]g/d, or calcium, 400 mg/d, women with rheumatoid arthritis exhibited higher spinal bone densities with estradiol than with calcium administration.
Also, doctors may believe preventive therapy for GIOP
is unnecessary if they taper patients off glucocorticoids quickly.
Such that the GIOP
machine be able to dispatch calls up to servants and radio modules developed to run in the FPGA environment.
is designed to provide 'out-of-the-box' interoperability between CORBA 2-compliant products while accommodating the broadest possible set of underlying protocol environments," said David Curtis, Chief Technology Officer, Expersoft.
The GIOP component is designed to accommodate the broadest possible market for distributed object technology.
Expersoft expects to be among the first companies with full commercially-available UNO implementations, since much of the GIOP specification is based on technology already in Expersoft's XShell.
The UNO specification and more specifically the GIOP developed by Expersoft create open standards that have the advantage of being cost effective to implement and can accommodate future market conditions.