GTP-binding protein


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GTP-binding protein

[¦jē‚tē¦pē ′bīn·diŋ ‚prō‚tēn]
(cell and molecular biology)
One of a large family of heterotrimeric or monomeric proteins that bind GTP (guanosine 5′-triphosphate) as intermediaries in intracellular signaling pathways. Also known as G protein.
References in periodicals archive ?
Ephedra monosperma had mostly degradome proteins (profilins, desiccation-related protein, the GTP-binding protein RAN-1, and ceramidase) and had only two secretome proteins that we could detect in this initial comparative study--serine carboxypeptidase and glucan endo-1,3-[beta]-glucosidase.
CgtA is a highly conserved essential GTP-binding protein, coded by the cgtA gene, belonging to Obg subfamily in prokaryotes (8).
ES-285 is thought to disrupt the cytoskeleton by targeting the activity of the GTP-binding protein Rho leading to death of tumour cells, and EDG is likely to play a major role in this cascade.
164) includes rhodopsin, the pigment that absorbs light; GTP-binding protein, or transducin; an enzyme called rhodopsin kinase; another called S-antigen; and a retinoid-(vitamin A-) binding protein.
An interesting phenomenon was that some proteins that are associated with cell growth, proliferation, differentiation, apoptosis, and death Isomatotropin, developmentally regulated GTP-binding protein 2, insulin-like growth factor binding, ATP-binding protein associated with cell differentiation, and interleukin-1[beta]-converting enzyme (ICE)-like apoptotic protease 5 [Fas-associating protein with Death Domain (MORT1)associated Caenorhabditis elegans cell death gene (CED-3) homolog] were correlated with age.
Molecular studies suggest that ES-285 may achieve this by targeting the activity of the GTP-binding protein Rho, a crucial factor for the formation of cytoskeletal fibres, cell migration and tumour cell proliferation, via the means of endothelial cell differentiation gene (EDG) receptor (i.
Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho.
Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins.
Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go.