Gamma-Aminobutyric Acid

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Gamma-Aminobutyric Acid

 

NH2CH2CH2CH2COOH, an acid formed by the decarboxylation of glutaminic acid under the action of the enzyme decarboxylase. In the body, metabolism of gamma-aminobutyric acid gives succinic acid, which participates in the tricarboxylic acid cycle. Free gamma-aminobutyric acid is found in many plants. In higher mammals gamma-aminobutyric acid is only found in the brain, where its concentration reaches 100 mg percent. Gamma-aminobutyric acid is assumed to exert a retarding action on nerve activity, which is apparently associated with its effect on the permeability of biological membranes.

References in periodicals archive ?
29,30) The wide-range lateral interaction, possibly mediated by electrical and GABAergic synaptic transmission, contributes to the response modulation.
Drugs that modulate GABAergic and glutamatergic neurotransmission have anxiolytic and antidepressant activities in rodent models of depression.
MS has also been shown to have an effect on the development of the GABAergic receptors because separated subjects show an increase in GABAa receptors (Kinkead et al.
Somogyi, "Massive autaptic self-innervation of GABAergic neurons in cat visual cortex", J.
Additionally, vanillin can allosterically modulate the GABAergic neurotransmission by enhancing the binding of the endogenous receptor agonist (Ha et al.
In the study, the investigators used GABAergic inhibitory neuron precursors called MGE -like cells that were derived from human embryonic stem cells.
In the study, the investigators used GABAergic inhibitory neuron precursors called MGE-like cells that were derived from human embryonic stem cells.
SVP increases the turnover of gammaaminobutyric acid (GABA) and thereby potentiates GABAergic functions in some specific brain regions thought to be involved in the control of seizure generation and propagation.
Other transmitter systems that might be involved in drug dependence include the orexin, GABAergic and cholinergic systems, as well as pharmacotherapies that act via these systems have been tested.
It is thought that the main mechanism of action of valproic acid which is another antiepileptic drug is related with strengthening of the GABAergic pathways.
Studies on dopaminergic and GABAergic markers in striatum reveals a decrease in the dopamine transporter in schizophrenia.