Interestingly, angustidine (2), angustine (4), nauclefine (3), angustoline (6) and harmane (7) were more potent BChE inhibitors compared to galanthamine
yn helpu ymladd ac arafu Alzeimher's.
Treating Alzheimer's with the cheaper alternative of galanthamine
, therefore, has the potential to improve the lives of thousands of people.
We also compared the effects of TDE with galanthamine
, a well-known AChE-I drug used to treat AD patients.
Prof Trevor Walker, of Alzeim, said: "We've been testing the theory that if we stressed the plants by growing them at altitude, they would produce more of the alkaloid galanthamine
Two small earlier studies have suggested that galanthamine
, a reversible acetylcholinesterase inhibitor, might be useful for alcohol dependence.
Dr Rhodri Clwyd Griffiths, of the National Botanic Garden in Wales, says the galanthamine
in the plants may also lead to cancer cures.
and his coworkers derived the two compounds, P11012 and P11149, from galanthamine
, an alkaloid substance found in the plant.
For example excellent AChE inhibitors such as physostigmine and the more recent addition, galanthamine
and huperzine A were isolated from Physostigma venenosum, Galanthus species and Huperzia serrata, respectively (Hostettmann et al.
This increase is primarily due to an increase in sales for our new products, Galanthamine
Hydrobromide, Cow-bezoar Detoxicating tables, Ganhai Stomach Recovery capsules, Camptothecine, VC Honeysuckle-fructusforsythiae tables and compound Salvia Root tablets.
In addition, the compounds showed greater inhibitory activity on AChE than galanthamine
, a well known acetylcholinesterase inhibitor (47).
By-products from daffodils, such as galanthamine
- to treat memory loss - could create lucrative markets.