Gamma-Aminobutyric Acid

(redirected from Gamma amino butyric acid)
Also found in: Dictionary, Medical.

Gamma-Aminobutyric Acid

 

NH2CH2CH2CH2COOH, an acid formed by the decarboxylation of glutaminic acid under the action of the enzyme decarboxylase. In the body, metabolism of gamma-aminobutyric acid gives succinic acid, which participates in the tricarboxylic acid cycle. Free gamma-aminobutyric acid is found in many plants. In higher mammals gamma-aminobutyric acid is only found in the brain, where its concentration reaches 100 mg percent. Gamma-aminobutyric acid is assumed to exert a retarding action on nerve activity, which is apparently associated with its effect on the permeability of biological membranes.

References in periodicals archive ?
CPP-109 or "vigabatrin/GVG to treat addiction" works by inhibiting an enzyme that normally breaks down gamma amino butyric acid (GABA), a dopamine- modulating neurotransmitter.
Benzodiazepines act on GABA- gamma amino butyric acid, the most important inhibitory neurotransmitter in the brain, to bring relief from the symptoms of anxiety and its related disorders.