Zealand Pharma's drive to further expand its development portfolio has led it to identify therapeutics that target diseases associated with intercellular communication processes specifically involving gap junctions
are essential for communication between the cumulus cells and oocytes and gap junctions
are involved in the regulation of oocyte maturation (1).
In the heart, for example, molecules flowing through gap junctions
help synchronize the contractions of the organ.
Our potential lies in our understanding of Gap Junction
Intercellular Communication, the dysfunction of which occasions numerous medical conditions.
It has been shown that in the process of oocyte maturation, meiotic resumption is associated with the loss of gap junctions
between the oocyte and the granulosa cells (3).
In general, the exchange of information between the billions of neurons that make up the neuronal forest takes place through two types of highly specialised structures: chemical synapses (the majority) and so-called gap junctions
(a substrate of one class of electrical synapse).
However, researchers from the University of Bristol's School of Biochemistry in collaboration with a team from the University of Bath, have shown that the very first trigger in this process is a flash of calcium which spreads like a wave back from the wound edge through gap junctions
that connect all the cells.
in the brain; physiological and pathological roles.
13 Gap junctions
are particularly important to your skin because it is highly dependent upon intercellular communication for vital metabolic processes related to growth and reproduction.
In ovaries, connexin 43 (Cx43), encoded by Gja1, has been found to be the main connexin expressed in developing follicles forming the gap junctions
coupling granulosa cells (20-23).
The preservation of cardiac electrical coupling is controlled primarily by cardiac myocyte gap junctions
Among the 14 topics are timing excitation and inhibition in the cortical network, gap junctions
and emergent rhythms, the feed-forward chain as a filter-amplifier motif, encoding and decoding target parameters in the primate parietofrontal system, stochastic synchrony in the olfactory bulb, and the large-scale computational modeling of the primary visual cortex.