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Gardner's syndrome should be suspected with the detection of osteoma in the craniofacial region.
Gardner's syndrome is an autosomal dominant disorder and a subtype of FAP.
9) Multiple carniofacial osteomas, along with cutaneous and soft-tissue tumors, can suggest a diagnosis of Gardner's syndrome (2) (Figure 13).
Diagnosing osteoma is therefore important and has a life saving potential because they can be the earliest presenting feature of Gardner's syndrome.
10 Multiple or recurring tumors may be found in association with different conditions10 which include Gardner's syndrome, myotonic dystrophy, Rubinstein-Taybi syndrome, sarcoidosis, trisomy 9 and Turner's syndrome.
Slovis said some children with hereditary diseases--including ataxiatelangiectasia, basal cell nevus syndrome, Cockayne's syndrome, Down syndrome, Fanconi's anemia, Gardner's syndrome, Nijmegen breakage syndrome, and Usher's syndrome--are extremely sensitive to radiation and should not be exposed at all, if possible.
Although pilomatricomas generally are isolated findings, they may be associated with systemic disorders such as Gardner's syndrome, myotonic dystrophy, and sarcoidosis.
These include ataxiatelangiectasia, Gardner's syndrome, and basal cell nevus syndrome.
12) A relationship also exists between aggressive fibromatosis and Gardner's syndrome; patients with Gardner's syndrome can also exhibit multiple desmoid tumors.