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A polypeptide hormone secreted by the pyloric mucosa which stimulates the pancreas to release pancreatic fluid and the stomach to release gastric acid.



a polypeptide hormone secreted by the mucous membrane of the pylorus of the stomach; it is secreted when the pylorus is stretched or acted on by chemical stimulants (for example, products of the decomposition of food) or impulses from the vagus nerves. Gastrin increases the secretion of gastric and pancreatic juices, as well as of bile, and alters the tone and motility of the stomach and intestines. An increase in the hydrochloric-acid content of the pylorus (when acidic gastric juice enters it) inhibits the secretion of gastrin. Two kinds of gastrin, which are very similar in structure and physiological properties, have been distinguished. Gastrin has been synthesized chemically.

References in periodicals archive ?
When immunoassays that measure the C-terminal epitope of bioactive gastrins (first-line assays) are used, almost all patients with ZES are correctly diagnosed.
Processing-independent assays have been useful as second-line assays for a few gastrinomas with truly normal or only slightly increased plasma concentrations of amidated gastrins (27, 38).
Clearance and acid-stimulating action of human big and little gastrins in duodenal ulcer subjects.
In clinical chemistry, the only well-indicated routine use of gastrin assays is in the diagnosis of gastrinomas, i.
The diagnosis was ascertained by increased serum concentrations of amidated gastrin, increased basal as well as pentagastrin-stimulated gastric acid secretion, gastroduodenoscopy, selective blood sampling from the portal vein (for gastrin measurements), abdominal computed tomography scanning, and somatostatin analog (octreotide) scintigraphy.
The median amidated gastrin concentration in normal serum was 10.
Long term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth and gastritis.
5] Nonstandard abbreviations: MTC, medullary thyroid carcinoma; MEN, multiple endocrine neoplasia; CT, calcitonin; and GT, gastrin.
Alignment of the active site sequences of CCK and gastrin (Fig.
1), whereas CCK-B receptors do not discriminate between sulfated and nonsulfated CCK-peptides or between CCK and gastrin peptides (for review, see references 1-3).
Gastrin hormone is a known modulator of gastric acid secretion, resulting in the development of gastric ulcer when overexpressed.
Results showed PL-induced rats had gastric mucosal damage, lesion ulcer, over-expression of acidity, gastrin and [H.