micro array

(redirected from GeneChip)

micro array

A semiconductor device that is used to detect the DNA makeup of a human cell. DNA chains comprise molecules that pair with each other, and micro arrays contain millions of DNA strands designed to mate with their other half as the liquefied human cells are poured over them. This "hybridization" process is then detectable by a laser.

Micro arrays are revolutionizing medicine by being able to pinpoint a very specific disease or the susceptibility to it. Sometimes called "biochips," Affymetrix (www.affymetrix.com) pioneered this technology with its GeneChip family. See Human Genome Project.


Micro Array Features
The square locations on this Affymetrix array are called "features," and each feature holds millions of identical DNA strands called "probes." The probes are built like semiconductor chips, one layer at a time. (Image courtesy of Affymetrix.)







Hybridization (Pairing)
The human DNA sample, which has been replicated millions of times and fragmented into short pieces, is washed over the micro array. The red balls depict biotin molecules that were adhered to the fragments, which "swim" around the probes for up to 16 hours. During that time, some strands will pair with the probes (the hybridization process). (Image courtesy of Affymetrix.)







Detection
The array is rinsed and washed with a fluorescent stain that clings to the biotin on the strands of the human sample that remain. A laser causes them to glow, and the DNA is analyzed (genotyped) based on which probes on the array they mated with. (Images courtesy of Affymetrix.)
Mentioned in ?
References in periodicals archive ?
Launched in March 2009, the FlashTag product line has provided a powerful standardized tool for investigating miRNA expression when coupled with the GeneChip miRNA Arrays.
GenoLogics has seamlessly integrated its Geneus solution, built for multiple genomics applications, with the Affymetrix GeneChip(R) platforms, GeneChip Operating Software (GCOS) and the new GeneChip(R) Command Console(TM) Software (AGCC).
Santa Clara, CA) announced that Johnson & Johnson (New Brunswick, NJ) is the first company to gain early access to the new GeneChip HighThroughputArray (HTA) Human Genome U133 Array, a standard 96-well plate which will have a GeneChip Human Genome U133 A array in each well.
Built on the success of the first-generation miRNA Array design, turnkey assay, and data analysis solution, the GeneChip miRNA 2.
As a GeneChip-compatible software provider, GeneGo is committed to seamlessly integrating its MetaCore platform with the Affymetrix GeneChip platform.
This program makes it easy for Lexicon Genetics and other biotech companies to get cost effective access to GeneChip technology to accelerate their drug discovery and development programs.
The Affymetrix GeneChip Scanner 3000 with AutoLoader is a microarray scanner designed and produced by the industry pioneer that invented the first microarray and scanner.
Through this agreement, participating institutions will gain widespread access to Affymetrix' standard and custom GeneChip arrays, instrumentation and software to monitor gene expression for use in their research and development activities.
The intuitive set of integrated instrument control and data organization tools supports all cartridge-based GeneChip arrays with a file-based system designed for easy data sharing, a streamlined workflow and ease of use.
Santa Clara, CA; 408-731-5086) announced its first GeneChip probe array product for the measurement and analysis of gene expression in a prokaryotic organism (bacterium).
As a GeneChip-compatible software provider, BIOBASE is committed to seamlessly integrating its applications with the Affymetrix GeneChip platform.
GeneChip rat expression analysis arrays have accelerated discovery in a wide range of scientific disciplines including toxicology, neurobiology and physiology.