Genetic Polymorphism


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Related to Genetic Polymorphism: Single nucleotide polymorphism

Genetic Polymorphism

 

the coexistence within a population of two or more different hereditary forms, which are in dynamic equilibrium for several or even many generations. Genetic polymorphism is most often caused either by the varying pressures and vectors (direction) of selection under different conditions (for example, at different seasons) or by the increased relative viability of heterozygotes. One type of genetic polymorphism—balanced genetic polymorphism—is characterized by a constant optimal correlation between polymorphic forms, deviation from which proves unfavorable for the species. Balanced genetic polymorphism regulates itself automatically (an optimal correlation of forms is established). The majority of genes in man and animals are in a state of balanced genetic polymorphism. Several forms of genetic polymorphism may be distinguished; analysis of these forms makes it possible to determine the effect of selection in natural populations.

REFERENCE

Timofeev-Resovskii, N. V., and Iu. M. Svirezhev. “O geneticheskom polimorfizme v populiatsiiakh.” Genetika, 1967, no. 10.
References in periodicals archive ?
It is presently unclear whether this association is influenced by individual susceptibility factors such as genetic polymorphisms of xenobiotic-metabolizing enzymes.
OBJECTIVES: This study was conducted to assess lung function decrement associated with metal components in particulate pollutants and genetic polymorphisms of glutathione S-transferase M1 and T1.
The first evidence of genetic polymorphism of the CYP2D6 gene was observation of homozygous CYP2D6 gene deletion (CYP2D6D allele) by Southern transfer in individuals demonstrating the PM phenotype for debrisoquine hydroxylase [19,34].
Previous studies demonstrated that the risk of EC has been associated with various factors such as nitrosamine carcinogens, alcohol intake, cigarette smoking, malnutrition, and genetic polymorphisms (5,8,10-13).
The results of the trial allow us to presume that the CSN1S2 genetic polymorphism in the two Chinese breed does not affect the [[alpha].
32) investigated whether genetic polymorphisms within Syntaxin 1A, VAMP2 and SNAP25 were associated with schizophrenia in Japanese population.
DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326.
The prevalence of the genetic polymorphism of CyP1A1, CYP3A5, PON1, GSTM1, GSTT1, GSTP1 and NAT2 xenobiotic polymorphism was significantly same in pesticide exposed and control subjects.
The genetic effect is large enough to justify partitioning and the genetic polymorphism is common enough to justify population-based recruitment, if [greater than or equal to] 4% of total variance is attributable to the genetic polymorphism, as represented by the area above the appropriate curves in Fig.
We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between lung cancer and genetic polymorphism using logistic regression models.
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.
The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement.