Epistasis

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epistasis

[ə′pis·tə·səs]
(genetics)
The suppression of the effect of one gene by another.
(medicine)
A checking or stoppage of a hemorrhage or other discharge.
(pathology)
A scum or film of substance floating on the surface of urine.

Epistasis

 

the interaction of two nonallelic genes (that is, genes that are at different loci) whereby one of them, called the epistatic gene, suppresses the effect of the other one, called the hypostatic gene. Phenotypically, epistasis is manifested as a deviation from the segregation that would be expected in digenetic inheritance; in this case, however, there is no violation of Mendel’s laws, inasmuch as the alleles of the interacting genes are distributed in complete conformity to the law of independent assortment, or combination.

References in periodicals archive ?
Second, reproductively active farmed populations may result in farm-derived larvae settling into wild aggregations, setting up the potential for future genetic interactions.
The increased attention that PCOS has gained over the past decade has influenced research projects to explore genetic interactions and predispositions, environmental issues, and the effects of new treatments.
For example, the genetic interactions between a pathogen and a herbaceous plant that dies back to an underground rootstock during winter or summer are likely to be quite different from those involving a tree species that lives for, several centuries.
Lastly and most importantly, a difficulty in estimating genetic interactions lies on sample size and statistical power.
We hypothesize that overt hybrid autoimmunity represents only the tip of the iceberg, and that there are many more subtle non-additive genetic interactions that affect both the plant immune system and growth.
The more information we acquire about genetic interactions, the more effective scientists can be in developing bench-to-bedside research," she added.
A companion study is under way to assess genetic interactions with diet on the risk of cardiovascular disease and diabetes.
The GNS effort proposes going beyond the cellular mapping of known circuitry to actually generate new insights into genetic interactions and a predictive understanding of the biology of organisms," said Shuler.
We are eager to apply genome-wide screening to identify, learn and target the complex genetic interactions in human cancer cells to improve patient care.
In addition, genetic interactions of this QTL with other genes including Ppd-1, Vrn-1, and 1DL QTL will be defined, informing breeders of what alleles can be selected simultaneously for additive or interactive effects on heading date and pleiotropic phenotypes.
Rounding out the session, mathematician Takeharu Yamanaka and research fellow Fred Parham of the NIEHS Laboratory of Computational Biology and Risk Analysis presented a new method of analyzing gene expression to infer genetic interactions, which can help identify signal transduction pathways crucial to the sequence of biochemical events that control cellular function.
Mutations ia genes like dsh and RhoA, and genetic interactions among them, suggested the existence of a Fz/RhoA signaling for for the stablishment of polarity, which could have some analogies to the JNK signaling pathway partially dissected for a very different process occurring during Drosophila development, dorsal closure.