genome

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genome:

see geneticsgenetics,
scientific study of the mechanism of heredity. While Gregor Mendel first presented his findings on the statistical laws governing the transmission of certain traits from generation to generation in 1856, it was not until the discovery and detailed study of the
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.

genome

the overall genetic constitution of an organism/species as constituted by the chromosomal makeup of every member (the term arises from a combination of the terms ‘gene’ and ‘chromosome’). See also GENETICS, HUMAN GENOME PROJECT.

Genome

 

a haploid chromosome set; the sum total of the genes localized in the individual set of chromosomes of a given organism. The term was introduced in 1920 by the German biologist H. Winkler. The genome is usually understood to mean the sum of the genes concentrated in the chromosomes, without taking into account the hereditary determinants connected with the structures of cytoplasm. In the gametes of diploid organisms, as well as in the cells of haploid organisms, there is one genome; in the somatic cells of diploid organisms there are two genomes. With an increase in ploidy of the cells, the number of genomes grows. In fertilization, the genomes of the paternal and maternal gametes unite. As a rule, genomes obtained from paternal and maternal gametes are homologous. Homology between all or some genomes exists in all but distant hybrids. Absolute homology of two genomes may be defined as the coinciding of the linear arrangement of the genes in every chromosome. This coinciding ensures the possibility of the normal conjugation of chromosomes in meiosis.

Changes in the number of chromosomes (for example, polyploidy or an increase or loss of individual chromosomes) are called genomic mutations. An organism in which one and the same genome is repeated several times is called au-topolyploid. An organism in which different genomes are combined is called allopolyploid. Wheats may serve as an example of the allopolyploids. The haploid number of chromosomes in hard wheat is 14, in soft wheat, 21; and in einkorn, seven. By hybridization and the study of the conjugation of chromosomes in meiosis, it was ascertained that in all wheats there is one common genome (genome A) made up of seven chromosomes. In hard and soft wheat there are two common genomes (genomes A, B), each having seven chromosomes. Finally, in soft wheat, there is still another special genome (genome D), also made up of seven chromosomes. Thus, the genomic formula for einkorn is AA and for hard wheat it is AABB. Soft wheat, which has arisen in the process of evolution by the crossing of three different wild cereals and by the doubling of the number of chromosomes in the hybrids, has the genomic formula AABBDD.

In the experiments of the Soviet geneticist G. D. Kar-pechenko, radish and cabbage genomes were combined for the first time in a hybrid organism. By means of corresponding crossings and cytological analysis, the origin of separate genomes can be established. For example, V. A. Rybin obtained (resynthesized) a cultivated plum by crossing the cherry plum and the sloe; thus it was established that the genome of a plum includes cherry plum and sloe genomes. Of great significance in understanding the structure and functioning of the genome have been the establishment of the structure of the molecules of nucleic acids (DNA and RNA) and of the mechanisms of their replication, and the establishment of the means of “tracing” and transmitting genetic information.

V. N. SOIFER and V. V. KHVOSTOVA

genome

[′jē‚nōm]
(genetics)
The genetic endowment of a species.
The haploid set of chromosomes.

genome

, genom
1. the full complement of genetic material within an organism
2. all the genes comprising a haploid set of chromosomes
References in periodicals archive ?
Indeed, a close look at the two genomes reveals striking similarities.
The International Rice Genome Sequencing Project, a 10-nation consortium, is also sequencing the japonica genome using bacterial artificial chromosome libraries, a more time-consuming but also more accurate approach.
A team headed by scientists in Massachusetts has announced the DNA sequence of a boxer named Tasha, a detailed comparison of the dog's genome with those of mice and people, and a study of genetic variation among dog breeds.
Because recombination along the chromosomes is averaged over the genetic history of the population at large, this should randomize any association between a given polymorphism and phenotype, or environmental influence, unless it is closely linked with specific alleles in the genome.
To elucidate the mechanisms underlying the emergence of the different HEV71 subgenotypes with potentially different pathogenic potentials, we examined the whole genome sequence of representative HEV71 isolates of HFMD patients from the Malaysia 1997 outbreak.
454 Life Sciences, an innovative developer of genome-scale sequencing technologies and a majority-owned subsidiary of CuraGen Corporation (NASDAQ: CRGN), has obtained an exclusive license for sole use of sequencing by synthesis and pyrophosphate based sequencing for whole genome applications from Pyrosequencing AB (Stockholm: PYRO A), a global technology solutions provider for the Applied Genomics market.
Controversies rage over who owns the information contained in the human genome, and over the ethics of cloning, gene-therapy trials, and most recently embryonic stem-cell research.
This is years ahead of the original schedule set by the government-funded Human Genome Project, but stiff competition from the private sector, particularly from Celera Genomics, is now setting the pace of scientific discovery.
Designed to simultaneously parse, annotate, test and compare hundreds of genomes, kGAP 2.
The availability of the rat genome sequence should also have a profound impact on toxicogenomics.
This relationship is so close that the virus' DNA has become part of the wasp's genome and is inherited by each new wasp generation.
The company's expertise in microbial genomics includes genome sequencing, genome analysis and custom bioinformatics.