Globin


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globin

[′glō·bən]
(biochemistry)
Any of a class of soluble histone proteins obtained from animal hemoglobins.

Globin

 

the albuminous part of the complex protein hemoglobin, which includes four globin chains. Up to 30 percent of the proteinaceous nitrogen of globin is found in the diamino acids (arginine, lysine, and histidine). This is also characteristic of the histones; however, in contrast to the latter, globin contains little tyrosine. The isoelectric point of globin is 7.5; it is readily soluble in water but is precipitated by alcohol or acetone. The bond between heme and globin is stable and broken only in an acidic environment. After detachment of the heme, the protein loses its native properties. The rate of synthesis of globin in the body is very high, owing to the frequent replacement of the erythrocytes. The synthesis of globin takes place at the sites where the erythrocytes are formed; in animals having nucleated erythrocytes, globin synthesis may be observed directly in the erythrocytes of the blood. Genetically induced anomalies in globin synthesis determine some “molecular” blood diseases, such as sickle-cell anemia and Mediterranean anemia. In some cases the difference of anomalous globin consists in the replacement of just one amino acid in the polypeptide chain.

A. A. BOLDYREV

References in periodicals archive ?
Subsequent beta globin sequencing revealed a heterozygous beta-plus thalassemia mutation, while analysis for alpha globin deletions revealed a heterozygous Southeast Asian (SEA) two-gene deletion, consistent with--/[alpha][alpha] alpha thalassemia minor.
Based on these facts, all of [beta]-thalassemia carriers that had [alpha]-globin genes deletion for alpha globin gene triplication/quadruplication were investigated to ensure that phenotypes of these cases are just related to [beta]-thalassemia and [alpha]-globin genes deletion as genetic factors.
With the aim of determining the therapeutic potency of the novel inducing compounds and studying the underlying regulatory mechanism of the embryonic and fetal human globin genes expression, various in vitro and in vivo screening platforms have been widely utilized.
Consumer tests have demonstrated that cooked hams prepared with the globin protein isolated with MaxiPro HSP were preferred in taste over hams prepared with pure plasma protein, or with traditionally decoloured globin protein.
Thalassemia consists of two main classes, alpha and beta thalassemia, in which the the respective globin genes are involvedThe pathophysiology of the thalassemias can be traced to the deleterious effects of the excessively produced globin-chain subunits that damage the red cell precursors and red cells, leading to profound anemia.
Hb variants, caused by production of abnormal globin chains (e.
In the present study, the significance of the beta globin gene haplotypes in the origin of the hemoglobinopathies was determined in 60 unrelated patients with Hb C and 66 patients with beta thalassemia.
In thalassemia the genetic defect, which could be either mutation or deletion, results in reduced rate of synthesis or no synthesis of one of the globin chains that make up hemoglobin.
Using this method for cloning rabbit globin cDNAs, we obtained roughly 100,000 colonies containing recombinant [alpha]- or [beta]-globin cDNAs per 1 [micro]g mRNA, of which 30-50% were full-length or nearly full-length.
Causes, Incidence, And Risk Factors Hemoglobin is made of two proteins: Alpha globin and beta globin.
They used a number of techniques to characterize globin E and found that it is responsible for storing and delivering oxygen to the retina.
As agents of natural selection, infectious diseases like malaria have played a major role in the evolution of human species by showing association between genetic variation in beta globin gene and protection from severe malaria due to P.