Globulins


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Related to Globulins: fibrinogen, Beta globulins, Serum globulins

Globulins

 

a group of animal and plant proteins very widely distributed in nature. Globulins belong to the group of globular proteins. They are soluble in dilute solutions of neutral salts and dilute acids and alkalies but are insoluble in water (with the exception of myosin and several other globulins). They are precipitated in a semi saturated solution of ammonium sulfate, a saturated magnesium sulfate solution (at 30° C), or a saturated sodium sulfate solution (at 37° C). The molecular weights of globulins vary from a few thousand to a million or more. Most globulins are simple proteins, but some (particularly blood serum globulins) are bound to carbohydrates or lipids. The globulin of thyroid iron— thyroglobulin (molecular weight, 630,000)—is the only protein containing iodine. The globulins of nerve tissue—neuroglobulin and neurostromin—are compounds with nucleic acids (nucleoproteins). In relation to both alcohol and temperature, plant globulins (for example, glycinin, edestin, and legumin) are more stable than animal globulins.

Globulins enter into the composition of cytoplasm, blood plasma, and lymph (higher animals and humans), fixing their buffer capacity and the body’s properties of immunity. In addition to globulins, blood plasma contains protein albumins, and the albumin/globulin ratio has diagnostic significance. Normally it is near two, but it falls in inflammatory ailments. Gamma-globulin is used in medicine.

References in periodicals archive ?
This study was planned to determine the changes in blood pressure, serum alkaline phosphatase, serum globulin, and A:G ratio in pregnant women and matched controls in the tertiary care teaching hospital of central Kerala, where tapioca is a staple food, since recent studies have reported more toxic and smaller yields of tapioca due to changes in environment.
20,21,29,30) With protein electrophoresis, avian species have been shown to have six protein fractions: prealbumin, albumin, and [alpha]-1, [alpha]-2, [beta], and [gamma] globulins.
However, the values of cholesterol, triglycerides, creatinine, total protein, albumin, globulins, A/G ratio, AST, MCV, and red blood cells were not significantly (Pgreater than 0.
In response to reduced levels of serum albumin, in breast cancer patients, the albumin to globulin ratio is lowered due to an increase in globulins, mainly immunoglobulins synthesized by lymphocytes to compensate for the reduced serum albumin.
In December 2012, the Food and Drug Administration (FDA) approved VariZIG, a varicella zoster immune globulin preparation (Cangene Corporation, Winnipeg, Canada) for use in the United States for postexposure prophylaxis of varicella for persons at high risk for severe disease who lack evidence of immunity to varicella * and for whom varicella vaccine is contraindicated (1).
HUMAN SEX HORMONE-BINDING GLOBULIN GENE EXPRESSION- MULTIPLE PROMOTERS AND COMPLEX ALTERNATIVE SPLICING.
This study was done to verify the significance of total and free thyroid hormones in relation with total serum proteins and albumin, globulin fractions in patients with chronic hepatitis B and healthy controls.
The weight of the evidence in this study does not support a causal association between early exposure to mercury from thimerosal-containing vaccines and immune globulins administered prenatally or during infancy and neuropsychological functioning at the age of 7 to 10 years," they concluded.
The total content of disulfide-linked amino acids increased by ~2-fold for both fractions, and calculations based on serum concentrations indicated that globulins represented ~16% of the total binding capacity for disulfide-linked amino acids.
He and his colleagues were the first to use immune globulins to treat narcolepsy.
In this study, we used antibodies raised against purified rice endosperm globulins and against glutelins and have demonstrated that similar proteins accumulate within protein bodies in the embryo.
In-Licensed Varicella Zoster Immune Globulin for United States and Canada