Glucuronic Acid


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glucuronic acid

[¦glü·kyə¦rän·ik ′as·əd]
(biochemistry)
C6H10O7 An acid resulting from oxidation of the CH2OH radical ofD-glucose to COOH; a component of many polysaccharides and certain vegetable gums. Also known as glycuronic acid.

Glucuronic Acid

 

one of the uronic acids, COH(CHOH)4COOH; it is formed in the body from glucose when the latter is oxidized by a primary alcohol group. It is optically active and dissolves readily in water. Melting point, 167°-172° C. D-glucuronic acid is widespread in the animal and vegetable worlds and is a component of acid mucopolysaccharides, some bacterial polysaccharides, triterpenoid saponins, hemicellulose, and gums. Free glucuronic acid is found in blood and urine in small quantities. Certain metabolic products, including some toxic products (phenol and cresol), as well as many medications, are discharged with the urine in the form of sister compounds of glucuronic acid (glucuronides). Conversions of glucuronic acid in all animals except the monkey and guinea pig, as well as in humans, lead to the biosynthesis of ascorbic acid. Body fluids and tissues of animals (especially the liver, kidneys, and spleen, and also malignant tumors) and bacterial and plant tissues contain the enzyme β-glucuronidase, which catalyzes the hydrolysis of β-glucuronides to free glucuronic acid and the corresponding aglycon.

G. A. SOLOV’EVA

References in periodicals archive ?
1999, "The reaction of hyaluronic acid and its monomers, glucuronic acid and N-acetylglucosamine, with reactive oxygen species," Carbohydr.
This highly branched polysaccharide is a complex mixture of Ca, Mg and K salts of arabic acid that contains galactose, rhamnose, glucuronic acid, 4-O-methyl glucuronic acid and arabinose residues (16).
Further: "Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid.
Phenytoin (DPH) is converted in the liver by parahydroxylation to 5-(p-hydroxyphenyl)-5-phenylhydantoin and then conjugated to glucuronic acid.
It contains glucuronic acid which helps the liver metabolise alcohol.
The metabolites of catechin are all excreted in the form of methylated and demethylated forms of the catechin ring and/or conjugates with glucuronic acid, sulfate, and glycine.
It is a safe product that delivers caffeine with a mix of B vitamins to the mouth for quick ingestion, and it does not contain the mystery chemicals found in some other energy products like Taurine or glucuronic acid.
VPA is normally metabolized by the liver via glucuronic acid conjugation, mitochondrial [beta]-oxidation, and cytoplasmic [omega]-oxidation (Fig.
Albumin transports unconjugated bilirubin to the liver where it is metabolized using glucuronic acid into direct bilirubin.
He said that in this brave new world, chefs would shun vegetables, such as carrots, and would instead use the molecules, which make up carrots - caroteniods, pectins, fructose and glucuronic acid - instead.
The supershort hyaluronic acid molecule has two repeats of glucuronic acid and glucosamine and a molecular weight of around 800.