glucuronide

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glucuronide

[glü′kyu̇r·ə‚nīd]
(biochemistry)
A compound resulting from the interaction of glucuronic acid with a phenol, an alcohol, or an acid containing a carboxyl group. Also known as glycuronide.
References in periodicals archive ?
As the comparative method, LC-MS/MS was deemed the gold standard and used to categorize samples that should test positive for opiates (morphine, hydromorphone, codeine, hydrocodone, 6-monoacetylmorphine, or glucuronide metabolites), oxycodone (oxycodone, oxymorphone, or oxymorphoneglucuronide), or methadone.
It was observed that the majority of silymarin compounds were excreted within 24 hours of ingestion, but substantial amounts of glucuronides, sulpho-glucuronides and diglucuronides were excreted for up to 48 hours.
The glucuronides were the major excreted form, with a total excretion equal to 1.
Although sulfates were well hydrolysed as glucuronides in the body, sulfates (especially, ICHQ sulfate) resisted enzymatic hydrolysis in vitro by mitochondrialysosomal and microsomal enzymes in both liver and kidney in contrast to glucuronides to them (Ref Table 3).
Most BPA was found in the urine as the glucuronide conjugate.
last] values observed for THCCOO glucuronide compared with THCCOOH in this study are likely a consequence of THCCOO-glucuronide's higher LOQ (5 [micro]g/L vs 1 [micro]g/L for THCCOOH).
The major peak eluting earlier was considered to be puerarin 7-O-[beta]-glucuronide and the latter puerarin 4'-O-[beta]-glucuronide on the basis of comparison of the relative retention times of daidzein glucuronides (Clarke et al.
Intestinal bacteria are often responsible for the deconjugation of biliary glucuronides into the parental xenobiotic (50), and indeed most of the fecal radioactivity was detected as unchanged BPA.
Unconjugated THC and 11-OH-THC are not detected or detected in low concentrations (11-OH-THC only) in urine and require enzymatic or tandem enzymatic-alkaline hydrolysis to cleave glucuronides (19,23-24).
It has been established in rodents, for example, that BPA is extensively metabolized to glucuronides (57-98%) and possibly sulfate conjugates (0-4%), leaving 1-12% unmetabolized BPA (18,19), thereby complicating both qualitative and quantitative determinations.
Based on MS peak areas and ranking in the 1-h and 3-h samples, the main XLR-11 metabolites were 2'-carboxy-XLR-11 (M27), UR-144 pentanoic acid (M28), 5-hydroxy-UR-144 (M29), 2'-carboxyUR-144 pentanoic acid (M15), and the 3 hydroxy XLR-11 glucuronides (M21, M18, M20).