anchor: a complex membrane-anchoring structure for proteins.
Signal transduction in macrophages by glycosylphosphatidylinositols
of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties.
anchor signal sequence enhances the immunogenicity of a DNA vaccine encoding Plasmodium falciparum sexualstage antigen, Pfs230.
The trypanosomatid protozoan Leishmania synthesizes a variety of glycosylphosphatidylinositol
(GPI GPI)-anchored molecules on its surface.
C]) is a 33- to 35-kDa glycoprotein attached to the cell membrane by a glycosylphosphatidylinositol
anchor; it is produced in most cell types, mainly by neurons (2).
C] is a monomeric, glycosylated, glycosylphosphatidylinositol
(GPI)-linked extracellular protein that appears to play a role in signal transduction (18) and/or in the maintenance of the proper copper ion concentration (19-21).
The disease is caused by deficient biosynthesis of a glycosylphosphatidylinositol
linker that anchors several complement and immunoregulatory surface proteins on erythrocytes, monocytes, neutrophils, lymphocytes, and platelets (28-31).
Mammalian trehalase is linked to membrane by a glycosylphosphatidylinositol anchor, and phosphatidylinositol-specific phospholipase C is required for the trehalase to be completely liberated from the membrane (5).
Trehalase is an ectoenzyme that is linked to membrane by a glycosylphosphatidylinositol anchor, and excretion of the enzyme can be influenced by renal injuries.