Har Gobind Khorana

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Khorana, Har Gobind

 

Born Jan 9, 1922, in Raipur, India. American biochemist of Indian descent. Member of the National Academy of Sciences of the USA (1966). Foreign member of the Academy of Sciences of the USSR (1971).

Khorana received a degree from Punjab University in 1945 and one from the University of Liverpool in 1948. He worked at the Federal Polytechnical School in Zurich from 1948 to 1950 and at Cambridge University in Great Britain from 1950 to 1952. He was head of the laboratory of organic chemistry at the University of British Columbia in Canada from 1952 to 1960. In 1960 he became one of the directors of the Institute of Enzyme Research at the University of Wisconsin in Madison (USA) and a professor at that university in 1962. Since 1970 he has worked at the Massachusetts Institute of Technology.

Khorana’s principal works are on the synthesis of nucleotides, coenzymes, and nucleic acids. He has made a great contribution toward interpreting the genetic code; he has synthesized the simplest genes and a 72-member polynucleotide with a succession of mononucleotides that corresponds to alanine transfer RNA. He was awarded the Nobel Prize in 1968 with R. Holley and M. Nirenberg.

WORKS

Some Recent Developments in the Chemistry of Phosphate Esters of Biological Interest. New York-London, 1961.

A. N. SHAMIN

References in periodicals archive ?
Few Indians like Amartya Sen, CV Raman and Har Gobind Khorana received Nobel Prize for their outstanding academic researches but they pursued their studies in foreign universities like Harvard, not in Indian ones," he said in his convocation address on the third day of his four-day private visit to Bangladesh.
Nobel Prize winner Har Gobind Khorana, an Indian-American biochemist who was credited with discovery of essential function of the DNA and construction of the first synthetic gene, was honored by Google in form of a doodle on Tuesday.
Summary: New Delhi [India], January 9 (ANI): Google on Tuesday celebrated the 96th birth anniversary of Indian-American Nobel prize-winning biochemist Har Gobind Khorana with a doodle.
The old timers at the university -- which produced some of the most distinguished personalities including the Nobel laureate and biotechnologist Har Gobind Khorana, NASA astronaut Kalpana Chawla and prime ministers Manmohan Singh and Inder Kumar Gujral -- believe that the university has failed to live up to its legacy over the years.
MARSHALL WARREN NIRENBERG shared a Nobel Prize in Physiology or Medicine in 1968 with Har Gobind Khorana and Robert W Holley for breaking the genetic code and describing how it operates in protein synthesis.
In the early 1970s, Har Gobind Khorana with a team of 17 colleagues spent years assembling a gene with 207 base-pairs.
Nirenberg, 1961; Severo Ochoa, 1965, y Har Gobind Khorana, 1969) (3-6), el desarrollo de metodos de secuenciacion de los acidos nucleicos (Sanger, 1977) (7), la tecnica de la amplificacion del ADN por reaccion en cadena de la polimerasa (PCR, por sus siglas en ingles: polymerase chain reaction) (Mullis, 1985) (8), el inicio del Proyecto Genoma Humano (1989), hasta el desciframiento del genoma humano (9,10); la aplicacion de la biologia molecular y la biotecnologia ha permitido los siguientes adelantos (11-14):
Gobind Khorana logro por primera vez la sintesis de un gene de un aminoacido; asimismo, se aislo por primera vez una enzima de restriccion, una sustancia capaz de cortar trozos de ADN en lugares especificos.
Michael Smith (1993) was born in the UK, became a Canadian citizen; did his studies at Manchester; was awarded Prize for work at UBC; he was a postdoctoral fellow under Har Gobind Khorana (see below -- Nobel Prize for Physiology/Medicine in 1968).
Of the two others who shared the prize, one was the Indian-born American chemist Har Gobind Khorana (b.
Gobind Khorana of the University of Wisconsin, and Dr.
Gobind Khorana in the departments of biology and chemistry at the Massachusetts Institute of Technology.