Har Gobind Khorana

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Khorana, Har Gobind

 

Born Jan 9, 1922, in Raipur, India. American biochemist of Indian descent. Member of the National Academy of Sciences of the USA (1966). Foreign member of the Academy of Sciences of the USSR (1971).

Khorana received a degree from Punjab University in 1945 and one from the University of Liverpool in 1948. He worked at the Federal Polytechnical School in Zurich from 1948 to 1950 and at Cambridge University in Great Britain from 1950 to 1952. He was head of the laboratory of organic chemistry at the University of British Columbia in Canada from 1952 to 1960. In 1960 he became one of the directors of the Institute of Enzyme Research at the University of Wisconsin in Madison (USA) and a professor at that university in 1962. Since 1970 he has worked at the Massachusetts Institute of Technology.

Khorana’s principal works are on the synthesis of nucleotides, coenzymes, and nucleic acids. He has made a great contribution toward interpreting the genetic code; he has synthesized the simplest genes and a 72-member polynucleotide with a succession of mononucleotides that corresponds to alanine transfer RNA. He was awarded the Nobel Prize in 1968 with R. Holley and M. Nirenberg.

WORKS

Some Recent Developments in the Chemistry of Phosphate Esters of Biological Interest. New York-London, 1961.

A. N. SHAMIN

References in periodicals archive ?
Gobind Khorana in the departments of biology and chemistry at the Massachusetts Institute of Technology.
Prof Har Gobind Khorana (1965): Genetic code of protein synthesis; basically the "recipe" of how we are put together.
Prof Har Gobind Khorana, top left, Sir Robert Robinson, top right and, inset left, Sir James Chadwick who helped develop the atom bomb, and right, Prof Rodney Porter
Gobind Khorana, another Nobel Laureate, at the British Columbia Research Council before he became head of the Chemistry Laboratory of the Fisheries Research Council of Canada, after becoming Professor of Biochemistry at the University of British Columbia, he studied with the renowned chemist and Nobel Laureate Fred Sanger at the Medical Research Council Laboratories in Cambridge, England.
Gobind Khorana, and residency training at the Massachusetts General Hospital, Harvard Medical School.
Har Gobind Khorana was awarded the Nobel Prize for medicine in 1968.
The old timers at the university -- which produced some of the most distinguished personalities including the Nobel laureate and biotechnologist Har Gobind Khorana, NASA astronaut Kalpana Chawla and prime ministers Manmohan Singh and Inder Kumar Gujral -- believe that the university has failed to live up to its legacy over the years.
MARSHALL WARREN NIRENBERG shared a Nobel Prize in Physiology or Medicine in 1968 with Har Gobind Khorana and Robert W Holley for breaking the genetic code and describing how it operates in protein synthesis.
In the same year, together with Har Gobind Khorana, he was awarded the Louisa Gross Horwitz Prize from Columbia University.
In the early 1970s, Har Gobind Khorana with a team of 17 colleagues spent years assembling a gene with 207 base-pairs.
Gobind Khorana at the Massachusetts Institute of Technology.
Michael Smith (1993) was born in the UK, became a Canadian citizen; did his studies at Manchester; was awarded Prize for work at UBC; he was a postdoctoral fellow under Har Gobind Khorana (see below -- Nobel Prize for Physiology/Medicine in 1968).