Goblet Cells


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Related to Goblet Cells: Paneth Cells, Crypts of Lieberkuhn

Goblet Cells

 

glandular epithelial cells in vertebrate animals and man that secrete mucus. Goblet cells are distributed individually in the mucous membranes of the intestine, air passages, efferent ducts of the pancreas and parotid glands, and the conjunctiva of the eyes. Goblet cells are formed from ordinary epithelial cells. The upper part of goblet cells, which is covered with microvilli, accumulates granules of secretion (mucinogen) that turn into a mass of mucus (mucin) when they absorb water. Goblet cells acquire the shape of a goblet (hence the name) when their apex swells and their base narrows. The upper part of the cells is then destroyed (apocrine secretion) and mucus is released into the lumen of the organ. The walls of the goblet cells collapse, become prismatic, and begin again to accumulate secretion.

N. V. NECHAEVA

References in periodicals archive ?
Consequently this appeared to promote absorption at the small intestine and proliferation of goblet cells thus maintaining normal morphology and mechanical barrier functions of the small intestinal mucosa.
9) This is demonstrated in the disease Stevens-Johnson syndrome, in which goblet cells are destroyed (most commonly by an acute reaction to antibiotic medication), leading to symblepharon, in which the tarsal and bulbar conjunctiva fuse together.
Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia.
8,9) These observations suggest that in response to irritation by infectious agents or chemical factors, the nasal mucosal epithelium, goblet cells, and glandular epithelium will proliferate reactively and produce anti-inflammatory agents, including PLUNC protein, as a defense against the irritant.
To calculate the number of goblet cells in non-infected, infected and infected-treated mice, jejunum tissue sections were stained with Alcian blue and the number of goblet cells was scored in 10 well orinted jejuna villi (Allen et al.
Nelson graded conjunctival impression cytology specimens (Grades 0-3, Table 1) based on the appearance of the epithelial cells and the numbers of goblet cells.
Intestinal goblet cells number in LPS group was not significantly different from the mice in control group (Figure 2).
The latter is called calcium-activated chloride channel (CaCC) channel, the channel has a very close relationship with asthma goblet cell hyperplasia, excessive airway mucus secretion, mucin gene expression and high reactivity in the airway.
C, Intestinal-type adenoma: the cells are pseudostratified, with occasional goblet cells and no apical mucin cap.
TFF2 is expressed in mucous neck cells, pyloric glands, and Brunner's glands, while intestinal trefoil factor (TFF3) is mainly expressed in goblet cells of the small and large intestines (Hoffmann et al.
The researchers showed that the resulting Club-iPL cells could give rise to Club cells and other respiratory tract cells such as mucus-secreting goblet cells and ciliated epithelial cells that produce the CFTR protein, which is mutated in patients with cystic fibrosis.
Mucosa was made up of simple columnar epithelium with goblet cells and the number of goblet cells decreased towards the apex of the villi (Firdous and Lucy, 2012).